Sharon Chung, MD
513 Parnassus Ave, Med Sci
San Francisco, CA 94122
Dr. Chung completed her MD (2001) at Johns Hopkins University where she was also an intern and resident (2001-04) in Internal Medicine. She was a Rheumatology Clinical Fellow at UCSF (2004-07), and joined the UCSF faculty in 2007. Dr. Chung completed a Master's Degree in Advanced Studies in Clinical Research at UCSF (2008).
The central goal of Dr. Chung's research program is to discover genetic and epigenetic factors that influence autoimmune disease susceptibility and its manifestations, in order to identify biologic pathways involved in disease pathogenesis and potential targets for therapeutic intervention. Current projects focused on systemic lupus erythematosus (SLE) include genome-wide association studies, more focused investigations of the major histocompatilibity complex, and DNA methylation studies of specific disease manifestations. Her clinical interest is systemic vasculitis, and she directs the UCSF Vasculitis Clinic. Her research activities in vasculitis include genetic, epigenetic, and transcriptional studies of small vessel vasculitides. The UCSF Vasculitis Clinic is a member of the Vasculitis Clinical Research Consortium (VCRC), and the clinic participates in ongoing VCRC studies.
Awards and Honors
Ephraim Engleman Award for Excellence in Arthritis Research, University of California, San Francisco, 2011
Distinguished Fellow Award, American College of Rheumatology, 2007
Recent Articles (25)
Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome. Case Rep Neurol Med. 2015; 2015:278287.
Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. PLoS One. 2015; 10(7):e0129813.
Home-use servo-ventilation therapy in chronic pain patients with central sleep apnea: initial and 3-month follow-up. Sleep Breath. 2015 Dec; 19(4):1285-92.
I'M SLEEPY: A short pediatric sleep apnea questionnaire. Int J Pediatr Otorhinolaryngol. 2014 Dec; 78(12):2116-20.
Weighing the balance: how analgesics used in chronic pain influence sleep? Br J Pain. 2014 Aug; 8(3):107-18.
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus. J Am Soc Nephrol. 2014 Dec; 25(12):2859-70.
MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun. 2014 Apr; 15(4):210-7.
PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013; 8(8):e69404.
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat Genet. 2012 Nov; 44(11):1227-30.
European genetic ancestry is associated with a decreased risk of lupus nephritis. Arthritis Rheum. 2012 Oct; 64(10):3374-82.
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. Arthritis Rheum. 2012 Oct; 64(10):3463-71.
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011 Dec; 7(12):e1002406.
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet. 2011 Mar; 7(3):e1001323.
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet. 2011 Feb; 7(2):e1001311.
Microscopic polyangiitis. Rheum Dis Clin North Am. 2010 Aug; 36(3):545-58.
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet. 2009 Oct; 5(10):e1000696.
European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent. Genes Immun. 2010 Sep; 11(6):515-21.
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet. 2009 Nov; 41(11):1228-33.
European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis Rheum. 2009 Aug; 60(8):2448-56.
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J Clin Invest. 2009 Apr; 119(4):911-23.
Advances in the use of biologic agents for the treatment of systemic vasculitis. Curr Opin Rheumatol. 2009 Jan; 21(1):3-9.
Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet. 2008 May; 4(5):e1000084.
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008 Feb 28; 358(9):900-9.
PTPN22: its role in SLE and autoimmunity. Autoimmunity. 2007 Dec; 40(8):582-90.
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