Milena Gianfrancesco, PhD, MPH

Assistant Professor

Education
BS, - Neuroscience; Italian Studies, Brown University
PhD, - Epidemiology; Designated Emphasis in Computational and Genomic Biology, University of California, Berkeley
MPH, - Chronic Disease Epidemiology, Yale University
Honors and Awards
  • Career Development Bridge Funding Award: K Supplement, Rheumatology Research Foundation, 2020
  • NIH Loan Repayment Program, National Institutes of Health, NIAMS, 2017
  • Lawren H. Daltroy Health Professional Preceptorship, Rheumatology Research Foundation, 2017
Publications
  1. Strangfeld A, Schäfer M, Gianfrancesco MA, Lawson-Tovey S, Liew JW, Ljung L, Mateus EF, Richez C, Santos MJ, Schmajuk G, Scirè CA, Sirotich E, Sparks JA, Sufka P, Thomas T, Trupin L, Wallace ZS, Al-Adely S, Bachiller-Corral J, Bhana S, Cacoub P, Carmona L, Costello R, Costello W, Gossec L, Grainger R, Hachulla E, Hasseli R, Hausmann JS, Hyrich KL, Izadi Z, Jacobsohn L, Katz P, Kearsley-Fleet L, Robinson PC, Yazdany J, Machado PM. Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry. 2021. PMID: 33504483


  2. Liew JW, Gianfrancesco MA, Heckbert SR, Gensler LS. The relationship between body mass index, disease activity, and exercise in ankylosing spondylitis. 2021. PMID: 33502113


  3. Gianfrancesco MA, Leykina LA, Izadi Z, Taylor T, Sparks JA, Harrison C, Trupin L, Rush S, Schmajuk G, Katz P, Jacobsohn L, Hsu TY, D'Silva KM, Serling-Boyd N, Wallwork R, Todd DJ, Bhana S, Costello W, Grainger R, Hausmann JS, Liew JW, Sirotich E, Sufka P, Wallace ZS, Machado PM, Robinson PC, Yazdany J. Race/ethnicity association with COVID-19 outcomes in rheumatic disease: Data from the COVID-19 Global Rheumatology Alliance Physician Registry. 2020. PMID: 33146001


  4. Izadi Z, Schmajuk G, Gianfrancesco M, Subash M, Evans M, Trupin L, Yazdany J. Rheumatology Informatics System for Effectiveness (RISE) Practices See Significant Gains in Rheumatoid Arthritis Quality Measures. 2020. PMID: 32937026


  5. Norgeot B, Quer G, Beaulieu-Jones BK, Torkamani A, Dias R, Gianfrancesco M, Arnaout R, Kohane IS, Saria S, Topol E, Obermeyer Z, Yu B, Butte AJ. Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist. 2020. PMID: 32908275


  6. Briggs FBS, Gianfrancesco MA, George MF. More on Covid-19 in Immune-Mediated Inflammatory Diseases. 2020. PMID: 32649070


  7. Gianfrancesco MA, McCulloch CE, Trupin L, Graf J, Schmajuk G, Yazdany J. Reweighting to address nonparticipation and missing data bias in a longitudinal electronic health record study. 2020. PMID: 32807591


  8. Gianfrancesco M, Hyrich KL, Yazdany J, Machado PM, Robinson PC. Response to: 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis' by Györfi et al. 2020. PMID: 32606045


  9. Anastasiou C, Trupin L, Glidden DV, Li J, Gianfrancesco M, Shiboski S, Schmajuk G, Yazdany J. Mortality among Hospitalized Individuals with Systemic Lupus Erythematosus in the United States between 2006 and 2016. 2020. PMID: 32558160


  10. Gianfrancesco M, Hyrich KL, Al-Adely S, Carmona L, Danila MI, Gossec L, Izadi Z, Jacobsohn L, Katz P, Lawson-Tovey S, Mateus EF, Rush S, Schmajuk G, Simard J, Strangfeld A, Trupin L, Wysham KD, Bhana S, Costello W, Grainger R, Hausmann JS, Liew JW, Sirotich E, Sufka P, Wallace ZS, Yazdany J, Machado PM, Robinson PC. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. 2020. PMID: 32471903


  11. Konig MF, Kim AH, Scheetz MH, Graef ER, Liew JW, Simard J, Machado PM, Gianfrancesco M, Yazdany J, Langguth D, Robinson PC. Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19. 2020. PMID: 32381561


  12. Gianfrancesco MA, Hyrich KL, Gossec L, Strangfeld A, Carmona L, Mateus EF, Sufka P, Grainger R, Wallace Z, Bhana S, Sirotich E, Liew J, Hausmann JS, Costello W, Robinson P, Machado PM, Yazdany J. Rheumatic disease and COVID-19: initial data from the COVID-19 Global Rheumatology Alliance provider registries. 2020. PMID: 32309814


  13. Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Rhead B, Barcellos LF, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Criswell LA. A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. 2019. PMID: 31467281


  14. Izadi Z, Katz PP, Schmajuk G, Gandrup J, Li J, Gianfrancesco M, Yazdany J. Effects of language, insurance and race/ethnicity on measurement properties of the PROMIS Physical Function Short Form 10a in rheumatoid arthritis. 2018. PMID: 30099861


  15. Ying D, Gianfrancesco MA, Trupin L, Yazdany J, Greidinger E, Schmajuk G. Increased risk of ischemic stroke in systemic sclerosis: a national cohort study of US veterans. 2019. PMID: 30877213


  16. Norgeot B, Glicksberg BS, Trupin L, Lituiev D, Gianfrancesco M, Oskotsky B, Schmajuk G, Yazdany J, Butte AJ. Assessment of a Deep Learning Model Based on Electronic Health Record Data to Forecast Clinical Outcomes in Patients With Rheumatoid Arthritis. 2019. PMID: 30874779


  17. Patterson S, Schmajuk G, Evans M, Aggarwal I, Izadi Z, Gianfrancesco M, Yazdany J. Gaps in Ambulatory Patient Safety for Immunosuppressive Specialty Medications. 2019. PMID: 30686706


  18. Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G. Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates. 2018. PMID: 30504507


  19. Schmajuk G, Jafri K, Evans M, Shiboski S, Gianfrancesco M, Izadi Z, Patterson SL, Aggarwal I, Sarkar U, Dudley RA, Yazdany J. Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs. 2018. PMID: 30449650


  20. Gianfrancesco MA, Tamang S, Yazdany J, Schmajuk G. Potential Biases in Machine Learning Algorithms Using Electronic Health Record Data. 2018. PMID: 30128552


  21. Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Volume 24. 2018. PMID: 30005356


  22. Li J, Yazdany J, Trupin L, Izadi Z, Gianfrancesco M, Goglin S, Schmajuk G. Capturing a Patient-Reported Measure of Physical Function Through an Online Electronic Health Record Patient Portal in an Ambulatory Clinic: Implementation Study. Volume 6 of Issue 2. 2018. PMID: 29743158


  23. Jafri K, Ogdie A, Qasim A, Patterson SL, Gianfrancesco M, Izadi Z, Katz P, Yazdany J, Schmajuk G. Discordance of the Framingham cardiovascular risk score and the 2013 American College of Cardiology/American Heart Association risk score in systemic lupus erythematosus and rheumatoid arthritis. Volume 37 of Issue 2. 2017. PMID: 28993952


  24. Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E. Genetic risk factors for pediatric-onset multiple sclerosis. 2017. PMID: 28980494


  25. Gianfrancesco MA, Schmajuk G, Haserodt S, Trupin L, Izadi Z, Jafri K, Shiboski S, Sirota M. Hydroxychloroquine dosing in immune-mediated diseases: implications for patient safety. Volume 37 of Issue 10. 2017. PMID: 28748425


  26. Hedström AK, Katsoulis M, Hössjer O, Bomfim IL, Oturai A, Sondergaard HB, Sellebjerg F, Ullum H, Thørner LW, Gustavsen MW, Harbo HF, Obradovic D, Gianfrancesco MA, Barcellos LF, Schaefer CA, Hillert J, Kockum I, Olsson T, Alfredsson L. The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. Volume 32 of Issue 10. 2017. PMID: 28597127


  27. Marshall DA, MacDonald KV, Robinson JO, Barcellos LF, Gianfrancesco M, Helm M, McGuire A, Green RC, Douglas MP, Goldman MA, Phillips KA. The price of whole-genome sequencing may be decreasing, but who will be sequenced? Volume 14 of Issue 3. 2017. PMID: 28993792


  28. Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Volume 88 of Issue 17. 2017. PMID: 28356466


  29. Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF. Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Volume 185 of Issue 3. 2017. PMID: 28073764


  30. Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Volume 2 of Issue 5. 2016. PMID: 27652346


  31. George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Volume 2 of Issue 4. 2016. PMID: 27540591


  32. Gianfrancesco MA, Balzer L, Taylor KE, Trupin L, Nititham J, Seldin MF, Singer AW, Criswell LA, Barcellos LF. Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation. Volume 17 of Issue 6. 2016. PMID: 27467283


  33. Hedström AK, Mowry EM, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Olsson T, Barcellos LF, Alfredsson L. High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. Volume 87 of Issue 5. 2016. PMID: 26940586


  34. Gianfrancesco MA, Barcellos LF. Obesity and Multiple Sclerosis Susceptibility: A Review. Volume 1 of Issue 7. 2016. PMID: 27990499


  35. Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, Bellesis KH, Bernstein A, Hedstrom AK, Kockum I, Alfredsson L, Olsson T, Schaefer C, Barcellos LF. Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Volume 8 of Issue 5. 2014. PMID: 25263833


  36. Hedström AK, Lima Bomfim I, Barcellos L, Gianfrancesco M, Schaefer C, Kockum I, Olsson T, Alfredsson L. Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Volume 82 of Issue 10. 2014. PMID: 24500647


  37. Gianfrancesco MA, Triche EW, Fawcett JA, Labas MP, Patterson TS, Lo AC. Speed- and cane-related alterations in gait parameters in individuals with multiple sclerosis. Volume 33 of Issue 1. 2010. PMID: 20952198


  38. Lo AC, Chang VC, Gianfrancesco MA, Friedman JH, Patterson TS, Benedicto DF. Reduction of freezing of gait in Parkinson's disease by repetitive robot-assisted treadmill training: a pilot study. Volume 7. 2010. PMID: 20946640