Arthur Weiss, MD, PhD

Professor

Research Interest:

The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.
Education
Residency, - Rheumatology, University of California, San Francisco
Honors and Awards
  • Eberly Lecture, U. Pittsburgh, 2019
  • Establishment of Arthur Weiss Lectureship in Rheumatology and Immunology, UCSF, 2019
  • Associate Member, European Molecular Biology Organization, 2017
  • Ephraim P. Engleman Memorial Lecture, American College of Rheumatology, 2016
  • Merit Award, NIH, NIAID, 2016
  • Frank and Shirley Fitch Lecture, University of Chicago, 2016
  • Lifetime Achievement Award, American Association of Immunologists, 2012
  • Lifetime Achievement in Mentoring Award, UCSF, 2012
  • Distinguished Investigator Award, American College of Rheumatology, 2004
  • Member, Institute of Medicine, 2004
  • Member, National Academy of Sciences, 2004
  • Fellow, American Academy of Arts and Sciences, 2003
  • American Association of Immunologists-Huang Foundation Meritorious Career Award, American Association of Immunologists, 2001
  • Forty-first Faculty Research Lecturer, UCSF, 1998
  • Lee C. Howley Prize, Arthritis Foundation, 1997
  • Junior Investigator Award, American Association of Immunologists, 1993
  • Henry Kunkel Young Investigator Award, American College of Rheumatology, 1990
  • Young Investigator Award, Western Society for Clinical Investigation, 1990
Websites
Publications
  1. Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A. Cbl-b deficiency prevents functional but not phenotypic T cell anergy. 2021. PMID: 33974042


  2. Laura M. Nocka, Jean K. Chung, Aubrianna Decker, Theresa Kadlecek, Arthur Weiss, John Kuriyan, Jay T. Groves. Bruton's Tyrosine Kinase Membrane Dynamics and Signaling. 2020. PMID:


  3. Raman S. Ganti, Wan-Lin Lo, Darren McAffee, Jay T. Groves, Arthur Weiss, Arup K. Chakraborty. How the T Cell Signaling Network Processes Information to Discriminate between Self and Cognate Ligands. 2020. PMID:


  4. Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A. CD45 functions as a signaling gatekeeper in T cells. 2019. PMID: 31641081


  5. Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. 2019. PMID: 31611699


  6. Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. 2019. PMID: 31455730


  7. Wang Y, Huynh W, Skokan TD, Lu W, Weiss A, Vale RD. CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. 2019. PMID: 30814157


  8. Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA. The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions. 2018. PMID: 30429161


  9. Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. 2018. PMID: 29915297


  10. Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA. Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. 2018. PMID: 29301754


  11. Courtney AH, Lo WL, Weiss A. TCR Signaling: Mechanisms of Initiation and Propagation. 2017. PMID: 29269020


  12. Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A. A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. 2017. PMID: 28735895


  13. Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J. IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level. Volume 198 of Issue 6. 2017. PMID: 28159902


  14. Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. 2016. PMID: 27932698


  15. Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. 2016. PMID: 27700984


  16. Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA. CD28 Costimulation: From Mechanism to Therapy. 2016. PMID: 27192564


  17. Smith GA, Uchida K, Weiss A, Taunton J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. 2016. PMID: 27018889


  18. Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. 2016. PMID: 26783323


  19. Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen. Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia. 2015. PMID:


  20. Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J. An extracatalytic function of CD45 in B cells is mediated by CD22. Volume 112 of Issue 47. 2015. PMID: 26561584


  21. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. 2015. PMID: 26517880


  22. Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. Small molecule inhibition of Csk alters affinity recognition by T cells. 2015. PMID: 26302204


  23. Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A. The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. 2015. PMID: 25990959


  24. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. 2015. PMID: 25799995


  25. Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. 2015. PMID: 25829543


  26. Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. Volume 194 of Issue 8. 2015. PMID: 25769918


  27. Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman, Kevan M Shokat, Ellen A Robey, Arthur Weiss. Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. 2015. PMID:


  28. Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. 2015. PMID: 25627829


  29. Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. 2015. PMID: 25287889


  30. Chakraborty AK, Weiss A. Insights into the initiation of TCR signaling. 2014. PMID: 25137454


  31. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Volume 111 of Issue 35. 2014. PMID: 25136127


  32. Schim van der Loeff I, Hsu LY, Saini M, Weiss A, Seddon B. Zap70 is essential for long-term survival of naive CD8 T cells. 2014. PMID: 25092893


  33. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Volume 15 of Issue 7. 2014. PMID: 24908390


  34. Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. 2014. PMID: 24843022


  35. Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. 2014. PMID: 24608041


  36. Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. 2014. PMID: 24596147


  37. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Volume 34 of Issue 8. 2014. PMID: 24515435


  38. Maria P. Frushicheva, Arthur Weiss, Arup K. Chakraborty. Investigation of Novel Zap-70 Functionality in T Cell Signaling Pathways using Computational Modeling. 2014. PMID:


  39. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. 2013. PMID: 23993652


  40. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. 2013. PMID: 23708189


  41. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. 2013. PMID: 23543053


  42. Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. 2013. PMID: 23530057


  43. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. Volume 190 of Issue 6. 2013. PMID: 23396948


  44. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Volume 6 of Issue 256. 2013. PMID: 23281368


  45. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. Volume 122 of Issue 12. 2012. PMID: 23114597


  46. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Volume 489 of Issue 7414. 2012. PMID: 22902503


  47. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. 2012. PMID: 22820255


  48. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. 2012. PMID: 22570807


  49. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. The membrane environment can promote or suppress bistability in cell signaling networks. 2012. PMID: 22332778


  50. Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A. Lymphocyte signaling: a Tuscan affair. 2011. PMID: 22179269


  51. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Volume 109 of Issue 1. 2011. PMID: 22135465


  52. Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression. 2011. PMID: 21966541


  53. Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. 2011. PMID: 21930792


  54. Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. 2011. PMID: 21917715


  55. Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T. Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. 2011. PMID: 21543337


  56. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. 2011. PMID: 21525931


  57. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. 2011. PMID: 21441934


  58. Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL. Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. 2011. PMID: 21245479


  59. Liontos LM, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, McGlade CJ. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. 2011. PMID: 21220694


  60. Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. 2010. PMID: 21037577


  61. Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. 2010. PMID: 20805505


  62. Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2. 2010. PMID: 20431621


  63. Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A. ZAP-70: an essential kinase in T-cell signaling. 2010. PMID: 20452964


  64. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Volume 32 of Issue 3. 2010. PMID: 20346773


  65. Michelle L. Hermiston, Vikas Gupta, Arthur Weiss. Chapter 95 CD45. 2010. PMID:


  66. Dragone LL, Shaw LA, Myers MD, Weiss A. SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. 2009. PMID: 19909366


  67. Weiss A. TCR signal transduction: opening the black box. 2009. PMID: 19801506


  68. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Volume 2 of Issue 66. 2009. PMID: 19366993


  69. Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. Volume 182 of Issue 7. 2009. PMID: 19299707


  70. Au-Yeung BB, Deindl S, Hsu LY, Palacios EH, Levin SE, Kuriyan J, Weiss A. The structure, regulation, and function of ZAP-70. 2009. PMID: 19290920


  71. Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP. The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. 2009. PMID: 19246339


  72. Zikherman J, Weiss A. Antigen receptor signaling in the rheumatic diseases. Volume 11 of Issue 1. 2009. PMID: 19232064


  73. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Volume 136 of Issue 2. 2009. PMID: 19167334


  74. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Volume 106 of Issue 2. 2009. PMID: 19129486


  75. Zikherman J, Weiss A. Alternative splicing of CD45: the tip of the iceberg. Volume 29 of Issue 6. 2008. PMID: 19100695


  76. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Volume 106 of Issue 2. 2008. PMID: 19098101


  77. Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. 2008. PMID: 19015530


  78. Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. 2008. PMID: 19001138


  79. Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B. The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. 2008. PMID: 18408722


  80. Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, Weiss A, Liston A, Goodnow CC. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. 2007. PMID: 18093540


  81. Schmalzigaug R, Phee H, Davidson CE, Weiss A, Premont RT. Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. 2007. PMID: 17565117


  82. Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J. Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. 2007. PMID: 17512407


  83. Chung SC, Limnander A, Kurosaki T, Weiss A, Korenbrot JI. Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. 2007. PMID: 17452533


  84. Balachandran P, Dragone L, Garrity-Ryan L, Lemus A, Weiss A, Engel J. The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence. 2007. PMID: 17235393


  85. Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, Weiss A. Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. 2006. PMID: 17110436


  86. Michelle L. Hermiston, Nicole M. Cresalia, Viola Lam, Allison L. Tan, Arthur Weiss. The Phenotypic Consequences of an Activating Mutation in the Juxtamembrane Wedge of CD45 Is Sensitive to Genetic Modifiers. 2006. PMID:


  87. Susan E Levin, Chao Zhang, Kevan Shokat, Arthur Weiss. Small molecule inhibition of ZAP-70 kinase activity. 2006. PMID:


  88. Weiss A. Discovering the TCR beta-chain by subtraction. 2005. PMID: 16116159


  89. Dragone LL, Myers MD, White C, Sosinowski T, Weiss A. SRC-like adaptor protein regulates B cell development and function. 2006. PMID: 16365426


  90. Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A. Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. 2005. PMID: 16327786


  91. Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A. The juxtamembrane wedge negatively regulates CD45 function in B cells. 2005. PMID: 16356861


  92. Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. 2005. PMID: 15923611


  93. Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. 2004. PMID: 15492005


  94. Arthur Weiss, John C Cambier. Lymphocyte activation. 2004. PMID:


  95. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. 2004. PMID: 15004555


  96. Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A. Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. 2004. PMID: 14993283


  97. Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. 2003. PMID: 14624253


  98. Hartgroves LC, Lin J, Langen H, Zech T, Weiss A, Harder T. Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. 2003. PMID: 12646565


  99. Zheng Xu, Michelle L. Hermiston, Arthur Weiss. Chapter 114 CD45. 2003. PMID:


  100. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. 2002. PMID: 12479826


  101. Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A. Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. 2002. PMID: 12138205


  102. Hermiston ML, Xu Z, Majeti R, Weiss A. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. 2002. PMID: 11781344


  103. Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. 2001. PMID: 12414720


  104. Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg JR. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. 2001. PMID: 11528386


  105. Ku GM, Yablonski D, Manser E, Lim L, Weiss A. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. 2001. PMID: 11157752


  106. Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. 2001. PMID: 11179692


  107. Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. 2001. PMID: 11135576


  108. Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A. Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. 2001. PMID: 11123350


  109. Lin J, Weiss A. T cell receptor signalling. 2001. PMID: 11148124


  110. Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. 2000. PMID: 11163182


  111. Tomlinson MG, Lin J, Weiss A. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. 2000. PMID: 11094263


  112. Kane LP, Lin J, Weiss A. Signal transduction by the TCR for antigen. 2000. PMID: 10781399


  113. Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. 2000. PMID: 10795738


  114. Sosinowski T, Pandey A, Dixit VM, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. 2000. PMID: 10662792


  115. Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. 1999. PMID: 10453000


  116. Finco TS, Yablonski D, Lin J, Weiss A. The adapter proteins LAT and SLP-76 are required for T-cell activation. 1999. PMID: 11232295


  117. Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A. Differential requirements for ZAP-70 in TCR signaling and T cell development. 1998. PMID: 9794398


  118. Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 1998. PMID: 9846483


  119. Weiss A, Schlessinger J. Switching signals on or off by receptor dimerization. 1998. PMID: 9708728


  120. Yablonski D, Kuhne MR, Kadlecek T, Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. 1998. PMID: 9665884


  121. Liao XC, Littman DR, Weiss A. Itk and Fyn make independent contributions to T cell activation. 1997. PMID: 9396778


  122. Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR. Itk negatively regulates induction of T cell proliferation by CD28 costimulation. 1997. PMID: 9221751


  123. Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. 1997. PMID: 9104812


  124. Qian D, Weiss A. T cell antigen receptor signal transduction. 1997. PMID: 9069257


  125. Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. 1996. PMID: 8947048


  126. Taylor N, Bacon KB, Smith S, Jahn T, Kadlecek TA, Uribe L, Kohn DB, Gelfand EW, Weiss A, Weinberg K. Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene. 1996. PMID: 8920891


  127. van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A. alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. 1996. PMID: 8934570


  128. Shapiro VS, Mollenauer MN, Greene WC, Weiss A. c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1. 1996. PMID: 8920856


  129. Wu J, Motto DG, Koretzky GA, Weiss A. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. 1996. PMID: 8673706


  130. Crooks ME, Littman DR, Carter RH, Fearon DT, Weiss A, Stein PH. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. 1995. PMID: 8524248


  131. Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. 1995. PMID: 7561679


  132. Weiss A, Kadlecek T, Iwashima M, Chan A, Van Oers N. Molecular and genetic insights into T-cell antigen receptor signaling. 1995. PMID: 7486651


  133. Howe LR, Weiss A. Multiple kinases mediate T-cell-receptor signaling. 1995. PMID: 7701563


  134. Katzav S, Sutherland M, Packham G, Yi T, Weiss A. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. 1994. PMID: 7798261


  135. Izquierdo M, Leevers SJ, Williams DH, Marshall CJ, Weiss A, Cantrell D. The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor. 1994. PMID: 7925576


  136. Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A. The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation. 1994. PMID: 8076596


  137. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. 1994. PMID: 8202712


  138. Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. 1994. PMID: 8202713


  139. Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. 1994. PMID: 8176201


  140. Law CL, Sidorenko SP, Chandran KA, Draves KE, Chan AC, Weiss A, Edelhoff S, Disteche CM, Clark EA. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. 1994. PMID: 8163536


  141. van Oers NS, Teh SJ, Irving BA, Tiong J, Weiss A, Teh HS. Production and characterization of monoclonal antibodies specific for the murine T cell receptor zeta chain. 1994. PMID: 7512608


  142. Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. 1994. PMID: 7509083


  143. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. 1994. PMID: 8293463


  144. Weiss A, Iwashima M, Irving B, van Oers NS, Kadlecek TA, Straus D, Chan A. Molecular and genetic insights into T cell antigen receptor signal transduction. 1994. PMID: 7887313


  145. Fraser JD, Straus D, Weiss A. Signal transduction events leading to T-cell lymphokine gene expression. 1993. PMID: 8363726


  146. Desai DM, Sap J, Schlessinger J, Weiss A. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. 1993. PMID: 8490965


  147. M. Iwashima, A. C. Chan, B. Irving, D. Straus, A. Weiss. Molecular Dissection of T-Cell Antigen Receptor Signal Transduction. 1993. PMID:


  148. Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. 1992. PMID: 1423621


  149. Chan AC, Irving BA, Weiss A. New insights into T-cell antigen receptor structure and signal transduction. 1992. PMID: 1418701


  150. Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. 1992. PMID: 1531699


  151. Weiss A, Chan AC, Iwashima M, Straus D, Irving BA. Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain. 1992. PMID: 1339649


  152. Weiss A, Irving BA, Tan LK, Koretzky GA. Signal transduction by the T cell antigen receptor. 1991. PMID: 1839225


  153. Weiss A, Desai D, Graber M, Picus J, Koretzky G. The regulation of T-cell antigen receptor signal transduction function. 1991. PMID: 1990543


  154. Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. 1991. PMID: 1846244


  155. Desai DM, Newton ME, Kadlecek T, Weiss A. Stimulation of the phosphatidylinositol pathway can induce T-cell activation. 1990. PMID: 2234059


  156. Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. T-lymphocyte-antigen interactions in transplant rejection. 1990. PMID: 2405272


  157. Goldsmith MA, Bockenstedt LK, Dazin P, Weiss A. Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor. 1989. PMID: 2573246


  158. Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. 1988. PMID: 2459194


  159. Goldsmith MA, Weiss A. New clues about T-cell antigen receptor complex function. 1988. PMID: 3076421


  160. Goldsmith MA, Weiss A. Function of the antigen receptor in T cell activation. 1988. PMID: 3063086


  161. Bernard Manger, John Imboden, Arthur Weiss. Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation. 1988. PMID:


  162. Imboden JB, Weiss A. The initiation of human T lymphocyte activation. 1988. PMID: 2845427


  163. Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain. 1987. PMID: 2825032


  164. Bockenstedt LK, Goldsmith MA, Koretzky GA, Weiss A. The activation of T lymphocytes. 1987. PMID: 2963355


  165. Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL. Functional competency of T cell antigen receptors in human thymus. 1987. PMID: 3500209


  166. Lanier LL, Serafini AT, Ruitenberg JJ, Cwirla S, Federspiel NA, Phillips JH, Allison JP, Weiss A. The gamma T-cell antigen receptor. 1987. PMID: 3320076


  167. Pelicci PG, Subar M, Weiss A, Dalla-Favera R, Littman DR. Molecular diversity of the human T-gamma constant region genes. 1987. PMID: 3112943


  168. Saito T, Weiss A, Gunter KC, Shevach EM, Germain RN. Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. 1987. PMID: 2955045


  169. Lancki DW, Weiss A, Fitch FW. Requirements for triggering of lysis by cytolytic T lymphocyte clones. 1987. PMID: 2953785


  170. Weiss A, Shields R, Newton M, Manger B, Imboden J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. 1987. PMID: 3104454


  171. Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. 1987. PMID: 2435832


  172. Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. 1987. PMID: 3104795


  173. Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. 1987. PMID: 3102973


  174. Weiss A, Imboden J, Hardy K, Stobo J. The role of the antigen receptor/T3 complex in T-cell activation. 1987. PMID: 2957896


  175. Manger B, Hardy KJ, Weiss A, Stobo JD. Differential effect of cyclosporin A on activation signaling in human T cell lines. 1986. PMID: 2422208


  176. Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J. The role of the T3/antigen receptor complex in T-cell activation. 1986. PMID: 2939858


  177. Imboden JB, Weiss A, Stobo JD. Transmembrane signalling by the T3-antigen receptor complex. 1985. PMID: 25291003


  178. Ohashi PS, Mak TW, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, Terhorst C, Stobo JD, Weiss A. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. 1985. PMID: 4033759


  179. Weiss A, Imboden J, Wiskocil R, Stobo J. The role of T3 in the activation of human T cells. 1984. PMID: 6203926


  180. Stuart FP, McKearn TJ, Weiss A, Fitch FW. Suppression of rat renal allograft rejection by antigen and antibody. 1980. PMID: 6989746


  181. Weiss A, Stuart FP, Fitch FW. Immune reactivity of cells from long-term rat renal allograft survivors. 1978. PMID: 151955


  182. Weiss A, Fitch FW, McKearn TJ, Stuart FP. Immunological memory is regulated in the enhanced rat renal allograft recipient. 1978. PMID: 351414


  183. Weiss A, Stuart FP, Fitch FW. Absence of immunologic memory in recipients of enhanced renal allografts. 1978. PMID: 162608


  184. McKearn TJ, Sarmiento M, Weiss A, Stuart FP, Fitch FW. Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies. 1978. PMID: 308442