Arthur Weiss, MD, PhD
Education
Honors and Awards
- Eberly Lecture, U. Pittsburgh, 2019
- Establishment of Arthur Weiss Lectureship in Rheumatology and Immunology, UCSF, 2019
- Associate Member, European Molecular Biology Organization, 2017
- Ephraim P. Engleman Memorial Lecture, American College of Rheumatology, 2016
- Merit Award, NIH, NIAID, 2016
- Frank and Shirley Fitch Lecture, University of Chicago, 2016
- Lifetime Achievement Award, American Association of Immunologists, 2012
- Lifetime Achievement in Mentoring Award, UCSF, 2012
- Distinguished Investigator Award, American College of Rheumatology, 2004
- Member, Institute of Medicine, 2004
- Member, National Academy of Sciences, 2004
- Fellow, American Academy of Arts and Sciences, 2003
- American Association of Immunologists-Huang Foundation Meritorious Career Award, American Association of Immunologists, 2001
- Forty-first Faculty Research Lecturer, UCSF, 1998
- Lee C. Howley Prize, Arthritis Foundation, 1997
- Junior Investigator Award, American Association of Immunologists, 1993
- Henry Kunkel Young Investigator Award, American College of Rheumatology, 1990
- Young Investigator Award, Western Society for Clinical Investigation, 1990
Websites
Publications
McCarthy EE, Yu S, Perlmutter N, Nakao Y, Naito R, Lin C, Riekher V, DeRisi J, Ye CJ, Weiss A, Ashouri JF. Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model. The Journal of clinical investigation 2024. PMID: 39589811
Weiss A. Peeking Into the Black Box of T Cell Receptor Signaling. Annual review of immunology 2023. PMID: 37788477
Tsai YL, Arias-Badia M, Kadlecek TA, Lwin YM, Srinath A, Shah NH, Wang ZE, Barber D, Kuriyan J, Fong L, Weiss A. TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments. Immunity 2023. PMID: 38091950
Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A. Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37307442
Lu W, Helou YA, Shrinivas K, Liou J, Au-Yeung BB, Weiss A. The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P2 replenishment in response to TCR signaling during T cell development and survival. Nature immunology 2022. PMID: 36581712
Yuan-Li Tsai, Marcel Arias Badia, Theresa A Kadlecek, Neel H Shah, Lawrence Fong, Arthur Weiss. Overcoming inhibitory constraints to TCR signaling by targeting the pH-sensitive phosphatase suppressor of T-cell receptor signaling 1 (STS1). The Journal of Immunology 2022. PMID:
Wen Lu, Ynes A Helou, Byron B Au-Yeung, Krishna Shrinivas, Jen Liou, Arthur Weiss. The phosphatidylinositol-transfer protein Nir3 modulates T cell development and function. The Journal of Immunology 2022. PMID:
Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A. ZAP70, too little, too much can lead to autoimmunity. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2021. PMID: 34923645
Huang F, Nguyen TT, Echeverria I, Ramachandran R, Cary DC, Paculova H, Sali A, Weiss A, Peterlin BM, Fujinaga K. Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2021. PMID: 34821217
Lu W, Skrzypczynska KM, Weiss A. Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2021. PMID: 34675079
Jeffrey Bluestone, Arthur Weiss. Frank W. Fitch, M.D. Ph.D., 1929–2021. The Journal of Immunology 2021. PMID:
Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A. Cbl-b deficiency prevents functional but not phenotypic T cell anergy. The Journal of experimental medicine 2021. PMID: 33974042
Lo WL, Weiss A. Adapting T Cell Receptor Ligand Discrimination Capability via LAT. Frontiers in immunology 2021. PMID: 33936119
Shen L, Matloubian M, Kadlecek TA, Weiss A. A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. Science signaling 2021. PMID: 33531381
Byron B Au-Yeung, Arthur Weiss, Wendy Zinzow-Kramer. Basal TCR signaling drives the functional heterogeneity of naïve CD4+ T cells. The Journal of Immunology 2020. PMID:
Wendy M. Zinzow-Kramer, Arthur Weiss, Byron B Au-Yeung. CD4+ T cells are more sensitive to inhibition of TCR signaling under Th17 polarizing conditions. The Journal of Immunology 2020. PMID:
Ynes Helou, Byron B Au-Yeung, Arthur Weiss. The phosphatidinositol-transfer protein Nir3 is a modulator of T cell development. The Journal of Immunology 2020. PMID:
Laura M. Nocka, Jean K. Chung, Aubrianna Decker, Theresa Kadlecek, Arthur Weiss, John Kuriyan, Jay T. Groves. Bruton's Tyrosine Kinase Membrane Dynamics and Signaling. Biophysical Journal 2020. PMID:
Raman S. Ganti, Wan-Lin Lo, Darren McAffee, Jay T. Groves, Arthur Weiss, Arup K. Chakraborty. How the T Cell Signaling Network Processes Information to Discriminate between Self and Cognate Ligands. Biophysical Journal 2020. PMID:
Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A. CD45 functions as a signaling gatekeeper in T cells. Science signaling 2019. PMID: 31641081
Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nature immunology 2019. PMID: 31611699
Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proceedings of the National Academy of Sciences of the United States of America 2019. PMID: 31455730
Wang Y, Huynh W, Skokan TD, Lu W, Weiss A, Vale RD. CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. The Journal of cell biology 2019. PMID: 30814157
Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA. The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions. Blood 2018. PMID: 30429161
Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nature immunology 2018. PMID: 29915297
Shah NH, Löbel M, Weiss A, Kuriyan J. Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. eLife 2018. PMID: 29547119
Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA. Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. Blood 2018. PMID: 29301754
Smith GA, Taunton J, Weiss A. IL-2Rß abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells. Science signaling 2017. PMID: 29259099
Courtney AH, Lo WL, Weiss A. TCR Signaling: Mechanisms of Initiation and Propagation. Trends in biochemical sciences 2017. PMID: 29269020
Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A. A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. Molecular cell 2017. PMID: 28735895
Hsu LY, Cheng DA, Chen Y, Liang HE, Weiss A. Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. The Journal of experimental medicine 2017. PMID: 28159798
Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J. IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level. Volume 198 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2017. PMID: 28159902
Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS discovery : advancing life sciences R & D 2016. PMID: 27932698
Ashouri JF, Weiss A. Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. Journal of immunology (Baltimore, Md. : 1950) 2016. PMID: 27940659
Skrzypczynska KM, Zhu JW, Weiss A. Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells. Immunity 2016. PMID: 27889108
Adam H. Courtney, Theresa A. Kadlecek, Byron Au-Yeung, Arthur Weiss. Abstract A074: A Zap70-dependent negative feedback loop governs Lck activation by CD45. Other Topics 2016. PMID:
Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. eLife 2016. PMID: 27700984
Weiss A. Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways. The Journal of experimental medicine 2016. PMID: 27353087
Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA. CD28 Costimulation: From Mechanism to Therapy. Immunity 2016. PMID: 27192564
Smith GA, Uchida K, Weiss A, Taunton J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nature chemical biology 2016. PMID: 27018889
Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. The Journal of experimental medicine 2016. PMID: 26783323
Adam H. Courtney, Hanna E. Sjolin-Goodfellow, Qinqin Ji, Theresa A. Kadlecek, Arthur R. Salomon, Arthur Weiss. Abstract B042: Regulation of Lck activity by a cryptic phosphosite. Immune Regulation of T Cell Responses/ Evolving Concepts in Cancer Immunology 2016. PMID:
Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen. Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia. Blood 2015. PMID:
Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J. An extracatalytic function of CD45 in B cells is mediated by CD22. Volume 112 of Issue 47. Proceedings of the National Academy of Sciences of the United States of America 2015. PMID: 26561584
Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. eLife 2015. PMID: 26517880
Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. Small molecule inhibition of Csk alters affinity recognition by T cells. eLife 2015. PMID: 26302204
Zhengshan Chen, Seyedmehdi Shojaee, Maike Buchner, Huimin Geng, Jae Woong Lee, Lars Klemm, Eugene Park, Ying Xim Tan, Anne Satterthwaite, Elisabeth Paietta, Stephen P. Hunger, Mignon L. Loh, Jae U. Jung, John E. Coligan, Silvia Bolland, Tak W. Mak, Andre Limnander, Hassan Jumaa, Michael Reth, Arthur Weiss, Clifford A. Lowell, Markus Müschen. Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia. Molecular and cellular biology 2015. PMID:
Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A. The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Science signaling 2015. PMID: 25990959
Weiss A, Stobo JD. Commentary: "The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level". Frontiers in immunology 2015. PMID: 25954271
Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature 2015. PMID: 25799995
Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proceedings of the National Academy of Sciences of the United States of America 2015. PMID: 25829543
Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. Volume 194 of Issue 8. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 25769918
Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman, Kevan M Shokat, Ellen A Robey, Arthur Weiss. Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nature immunology 2015. PMID:
Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. Journal of clinical immunology 2015. PMID: 25627829
Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. The Biochemical journal 2015. PMID: 25287889
Chakraborty AK, Weiss A. Insights into the initiation of TCR signaling. Nature immunology 2014. PMID: 25137454
Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Volume 111 of Issue 35. Proceedings of the National Academy of Sciences of the United States of America 2014. PMID: 25136127
Schim van der Loeff I, Hsu LY, Saini M, Weiss A, Seddon B. Zap70 is essential for long-term survival of naive CD8 T cells. Journal of immunology (Baltimore, Md. : 1950) 2014. PMID: 25092893
Ross JO, Melichar HJ, Au-Yeung BB, Herzmark P, Weiss A, Robey EA. Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proceedings of the National Academy of Sciences of the United States of America 2014. PMID: 24927565
Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Volume 15 of Issue 7. 2014. PMID: 24908390
Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. eLife 2014. PMID: 24843022
Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nature immunology 2014. PMID: 24608041
Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. eLife 2014. PMID: 24596147
Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Volume 34 of Issue 8. 2014. PMID: 24515435
Maria P. Frushicheva, Arthur Weiss, Arup K. Chakraborty. Investigation of Novel Zap-70 Functionality in T Cell Signaling Pathways using Computational Modeling. Biophysical Journal 2014. PMID:
Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nature immunology 2013. PMID: 24317039
Weiss A. Tony Pawson: Modular protein domains and the links to intracellular signaling. Proceedings of the National Academy of Sciences of the United States of America 2013. PMID: 24135003
Tan YX, Zikherman J, Weiss A. Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. Volume 78. 2013. PMID: 24100586
Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity 2013. PMID: 23993652
Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nature genetics 2013. PMID: 23708189
Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. The Journal of clinical investigation 2013. PMID: 23543053
Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Molecular and cellular biology 2013. PMID: 23530057
Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. Volume 190 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2013. PMID: 23396948
Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Volume 6 of Issue 256. 2013. PMID: 23281368
Arthur Weiss, Jayajit Das, Annalisa M. VanHook. Science Signaling Podcast: 1 January 2013. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2013. PMID:
Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. Volume 122 of Issue 12. The Journal of clinical investigation 2012. PMID: 23114597
Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Volume 489 of Issue 7414. 2012. PMID: 22902503
Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 2012. PMID: 22820255
Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell reports 2012. PMID: 22570807
Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. The membrane environment can promote or suppress bistability in cell signaling networks. The journal of physical chemistry. B 2012. PMID: 22332778
Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A. Lymphocyte signaling: a Tuscan affair. Nature immunology 2011. PMID: 22179269
Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Volume 109 of Issue 1. Proceedings of the National Academy of Sciences of the United States of America 2011. PMID: 22135465
Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. Volume 121 of Issue 12. The Journal of clinical investigation 2011. PMID: 22080861
Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity 2011. PMID: 22078799
Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression. PloS one 2011. PMID: 21966541
Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. Molecular and cellular biology 2011. PMID: 21930792
Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Science signaling 2011. PMID: 21917715
Limnander A, Weiss A. Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells. Small GTPases 2011. PMID: 22292132
Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T. Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. The Journal of biological chemistry 2011. PMID: 21543337
Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 2011. PMID: 21525931
Byron Au-Yeung, Debra Cheng, Chao Zhang, Kevan Shokat, Arthur Weiss. A genetically selective inhibitor reveals ZAP-70 kinase-dependent checkpoints in T cell development (64.15). The Journal of Immunology 2011. PMID:
Ying Xim Tan, Jamie Schoenborn, Chao Zhang, Kevan Shokat, Arthur Weiss. A novel analog-sensitive allele of Csk reveals its kinase-independent role in the regulation of T cell receptor signaling (109.35). The Journal of Immunology 2011. PMID:
Robyn Mills, Viola Lam, Diana Tobler, Nir Oksenberg, Nicole Cresalia, Mark Anderson, Jian-Hua Mao, Arthur Weiss, Michelle Hermiston. Impact of TLR9 on hyper-responsive ITAM signaling in a mouse model of SLE (47.24). The Journal of Immunology 2011. PMID:
Hyewon Phee, Ivan Dzhagalov, Marianne Mollenauer, Yana Wang, Darrell Irvine, Ellen Robey, Arthur Weiss. Regulation of thymocyte positive selection and motility by GIT2 (113.9). The Journal of Immunology 2011. PMID:
Andre Limnander, Philippe Depeille, Tanya Freedman, Jen Liou, Michael Leitges, Tomohiro Kurosaki, Jeroen Roose, Arthur Weiss. Stim1, PKCd and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (109.6). The Journal of Immunology 2011. PMID:
Julie Zikherman, Kristin Doan, William Raschke, Arthur Weiss. Titration of CD45 expression regulates sequential tolerance checkpoints during B cell development (45.2). The Journal of Immunology 2011. PMID:
Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nature immunology 2011. PMID: 21441934
Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL. Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood 2011. PMID: 21245479
Liontos LM, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, McGlade CJ. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. Journal of immunology (Baltimore, Md. : 1950) 2011. PMID: 21220694
Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nature immunology 2010. PMID: 21037577
Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proceedings of the National Academy of Sciences of the United States of America 2010. PMID: 20805505
Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2. Nature immunology 2010. PMID: 20431621
Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A. ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harbor perspectives in biology 2010. PMID: 20452964
Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Volume 32 of Issue 3. 2010. PMID: 20346773
Weiss A. The right team at the right time to go for a home run: tyrosine kinase activation by the TCR. Nature immunology 2010. PMID: 20084063
Michelle L. Hermiston, Vikas Gupta, Arthur Weiss. Chapter 95 CD45. Handbook of Cell Signaling 2010. PMID:
Deindl S, Kadlecek TA, Cao X, Kuriyan J, Weiss A. Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19920178
Dragone LL, Shaw LA, Myers MD, Weiss A. SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunological reviews 2009. PMID: 19909366
Hsu LY, Tan YX, Xiao Z, Malissen M, Weiss A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. The Journal of experimental medicine 2009. PMID: 19841086
Weiss A. TCR signal transduction: opening the black box. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 19801506
Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Volume 2 of Issue 66. 2009. PMID: 19366993
Jamie R Schoenborn, Chao Zhang, Kevan M Shokat, Arthur Weiss. A chemical-genetic approach to inhibit Csk activates T cells independently of the T cell receptor (35.4). The Journal of Immunology 2009. PMID:
Lih-Yun Hsu, Ying-Xim Tan, Arthur Weiss. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity (49.6). The Journal of Immunology 2009. PMID:
Julie Zikherman, Susan Watson, Craig Jenne, William C. Raschke, Christopher Goodnow, Arthur Weiss. An allelic series of CD45 dosages uncouples basal and inducible TCR signaling during thymic development (84.13). The Journal of Immunology 2009. PMID:
Byron B Au-Yeung, Susan E Levin, Chao Zhang, Kevan Shokat, Arthur Weiss. Identifying ZAP-70 kinase-dependent and -independent functions in T cells using a chemical genetic approach (35.5). The Journal of Immunology 2009. PMID:
Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. Volume 182 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 19299707
Hyewon Phee, Marianne N. Mollenauer, Arthur Weiss. Role of GIT2 in T cell migration and development (95.8). The Journal of Immunology 2009. PMID:
Au-Yeung BB, Deindl S, Hsu LY, Palacios EH, Levin SE, Kuriyan J, Weiss A. The structure, regulation, and function of ZAP-70. Immunological reviews 2009. PMID: 19290920
Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP. The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 2009. PMID: 19246339
Zikherman J, Weiss A. Antigen receptor signaling in the rheumatic diseases. Volume 11 of Issue 1. 2009. PMID: 19232064
Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Volume 136 of Issue 2. 2009. PMID: 19167334
Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Volume 106 of Issue 2. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19129486
Zikherman J, Weiss A. Alternative splicing of CD45: the tip of the iceberg. Volume 29 of Issue 6. 2008. PMID: 19100695
Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Volume 106 of Issue 2. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19098101
Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19015530
Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. The Journal of experimental medicine 2008. PMID: 19001138
Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B. The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nature immunology 2008. PMID: 18408722
Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. The Journal of biological chemistry 2008. PMID: 18378687
Zhu JW, Brdicka T, Katsumoto TR, Lin J, Weiss A. Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 2008. PMID: 18249142
Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, Weiss A, Liston A, Goodnow CC. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 2007. PMID: 18093540
Palacios EH, Weiss A. Distinct roles for Syk and ZAP-70 during early thymocyte development. The Journal of experimental medicine 2007. PMID: 17606633
Schmalzigaug R, Phee H, Davidson CE, Weiss A, Premont RT. Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007. PMID: 17565117
Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J. Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell 2007. PMID: 17512407
Chung SC, Limnander A, Kurosaki T, Weiss A, Korenbrot JI. Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. The Journal of cell biology 2007. PMID: 17452533
Hyewon Phee, Arthur Weiss. Generation and characterization of GIT1 and GIT2 deficient mice (87.18). The Journal of Immunology 2007. PMID:
Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Molecular and cellular biology 2007. PMID: 17283063
Balachandran P, Dragone L, Garrity-Ryan L, Lemus A, Weiss A, Engel J. The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence. The Journal of clinical investigation 2007. PMID: 17235393
Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, Weiss A. Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proceedings of the National Academy of Sciences of the United States of America 2006. PMID: 17110436
Michelle L. Hermiston, Nicole M. Cresalia, Viola Lam, Allison L. Tan, Arthur Weiss. The Phenotypic Consequences of an Activating Mutation in the Juxtamembrane Wedge of CD45 Is Sensitive to Genetic Modifiers. Blood 2006. PMID:
Liguang Chen, Lang Huynh, Arthur Weiss, Thomas J. Kipps. ZAP-70 Enhances IgM Signaling in Chronic Lymphocytic Leukemia Cells Independent of Its Tyrosine Kinase Activity. Blood 2006. PMID:
Nirula A, Ho M, Phee H, Roose J, Weiss A. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. The Journal of experimental medicine 2006. PMID: 16785309
Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proceedings of the National Academy of Sciences of the United States of America 2006. PMID: 16627620
Susan E Levin, Chao Zhang, Kevan Shokat, Arthur Weiss. Small molecule inhibition of ZAP-70 kinase activity. The FASEB Journal 2006. PMID:
Dragone LL, Myers MD, White C, Sosinowski T, Weiss A. SRC-like adaptor protein regulates B cell development and function. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16365426
Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A. Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nature immunology 2005. PMID: 16327786
Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 2005. PMID: 16356861
Weiss A. Discovering the TCR beta-chain by subtraction. Journal of immunology (Baltimore, Md. : 1950) 2005. PMID: 16116159
Myers MD, Dragone LL, Weiss A. Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. The Journal of cell biology 2005. PMID: 16027224
Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Molecular and cellular biology 2005. PMID: 15899849
Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Molecular and cellular biology 2005. PMID: 15923611
Phee H, Abraham RT, Weiss A. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nature immunology 2005. PMID: 15864311
Levin SE, Weiss A. Twisting tails exposed: the evidence for TCR conformational change. The Journal of experimental medicine 2005. PMID: 15728230
Palacios EH, Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 2004. PMID: 15489916
Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. The Journal of biological chemistry 2004. PMID: 15492005
Lin J, Zhu JW, Baker JE, Weiss A. Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells. Journal of immunology (Baltimore, Md. : 1950) 2004. PMID: 15294945
Arthur Weiss, John C Cambier. Lymphocyte activation. Current opinion in immunology 2004. PMID:
Kane LP, Mollenauer MN, Weiss A. A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse. Journal of immunology (Baltimore, Md. : 1950) 2004. PMID: 15100285
Crotzer VL, Mabardy AS, Weiss A, Brodsky FM. T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. The Journal of experimental medicine 2004. PMID: 15067034
Abraham RT, Weiss A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nature reviews. Immunology 2004. PMID: 15057788
Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nature immunology 2004. PMID: 15004555
Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A. Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Molecular and cellular biology 2004. PMID: 14993283
Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS biology 2003. PMID: 14624253
Lin J, Weiss A. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. The Journal of cell biology 2003. PMID: 12913111
Kuhné MR, Lin J, Yablonski D, Mollenauer MN, Ehrlich LI, Huppa J, Davis MM, Weiss A. Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 12847255
Kane LP, Weiss A. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunological reviews 2003. PMID: 12670391
Hartgroves LC, Lin J, Langen H, Zech T, Weiss A, Harder T. Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. The Journal of biological chemistry 2003. PMID: 12646565
Zheng Xu, Michelle L. Hermiston, Arthur Weiss. Chapter 114 CD45. Handbook of Cell Signaling 2003. PMID:
Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity 2002. PMID: 12479826
Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A. Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Molecular and cellular biology 2002. PMID: 12138205
Kane LP, Lin J, Weiss A. It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. Trends in immunology 2002. PMID: 12133805
Xu Z, Weiss A. Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nature immunology 2002. PMID: 12134145
Xu Z, Stokoe D, Kane LP, Weiss A. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002. PMID: 12133897
Hermiston ML, Xu Z, Majeti R, Weiss A. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. The Journal of clinical investigation 2002. PMID: 11781344
Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annual review of immunology 2001. PMID: 12414720
Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg JR. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nature genetics 2001. PMID: 11528386
Sosinowski T, Killeen N, Weiss A. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 2001. PMID: 11567635
Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. The Journal of biological chemistry 2001. PMID: 11487585
Majeti R, Weiss A. Regulatory mechanisms for receptor protein tyrosine phosphatases. Chemical reviews 2001. PMID: 11749382
Shapiro VS, Mollenauer MN, Weiss A. Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression. Blood 2001. PMID: 11418479
Yablonski D, Kadlecek T, Weiss A. Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Molecular and cellular biology 2001. PMID: 11390650
Lin J, Weiss A. Identification of the minimal tyrosine residues required for linker for activation of T cell function. The Journal of biological chemistry 2001. PMID: 11395491
Lynch KW, Weiss A. A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer. The Journal of biological chemistry 2001. PMID: 11306584
Baker JE, Majeti R, Tangye SG, Weiss A. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Molecular and cellular biology 2001. PMID: 11259588
Ku GM, Yablonski D, Manser E, Lim L, Weiss A. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. The EMBO journal 2001. PMID: 11157752
Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Gene 2001. PMID: 11179692
Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nature immunology 2001. PMID: 11135576
Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A. Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. Journal of immunology (Baltimore, Md. : 1950) 2001. PMID: 11123350
Yablonski D, Weiss A. Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. Advances in immunology 2001. PMID: 11680012
Lin J, Weiss A. T cell receptor signalling. Journal of cell science 2001. PMID: 11148124
Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 2000. PMID: 11163182
Tomlinson MG, Lin J, Weiss A. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunology today 2000. PMID: 11094263
Kane LP, Lin J, Weiss A. Signal transduction by the TCR for antigen. Current opinion in immunology 2000. PMID: 10781399
Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity 2000. PMID: 10795738
Sosinowski T, Pandey A, Dixit VM, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. The Journal of experimental medicine 2000. PMID: 10662792
Kuhne MR, Ku G, Weiss A. A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. The Journal of biological chemistry 2000. PMID: 10636924
Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D. Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. The Journal of experimental medicine 2000. PMID: 10637279
Lynch KW, Weiss A. A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Molecular and cellular biology 2000. PMID: 10594010
Lin J, Weiss A, Finco TS. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. The Journal of biological chemistry 1999. PMID: 10506128
Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. Journal of immunology (Baltimore, Md. : 1950) 1999. PMID: 10453000
Lagunoff M, Majeti R, Weiss A, Ganem D. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proceedings of the National Academy of Sciences of the United States of America 1999. PMID: 10318948
Zhao Q, Williams BL, Abraham RT, Weiss A. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Molecular and cellular biology 1999. PMID: 9858619
Finco TS, Yablonski D, Lin J, Weiss A. The adapter proteins LAT and SLP-76 are required for T-cell activation. Cold Spring Harbor symposia on quantitative biology 1999. PMID: 11232295
Shapiro VS, Mollenauer MN, Weiss A. Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9862666
Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A. Differential requirements for ZAP-70 in TCR signaling and T cell development. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9794398
Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 1998. PMID: 9846483
Yablonski D, Kane LP, Qian D, Weiss A. A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. The EMBO journal 1998. PMID: 9755165
Weiss A, Schlessinger J. Switching signals on or off by receptor dimerization. Cell 1998. PMID: 9708728
Yablonski D, Kuhne MR, Kadlecek T, Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science (New York, N.Y.) 1998. PMID: 9665884
AnthonyL DeFranco, Arthur Weiss. Lymphocyte activation and effector functions Turning lymphocytes on and off. Current opinion in immunology 1998. PMID:
Grazioli L, Germain V, Weiss A, Acuto O. Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions. The Journal of biological chemistry 1998. PMID: 9535874
van Oers NS, Love PE, Shores EW, Weiss A. Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9551968
Liao XC, Littman DR, Weiss A. Itk and Fyn make independent contributions to T cell activation. The Journal of experimental medicine 1997. PMID: 9396778
Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR. Itk negatively regulates induction of T cell proliferation by CD28 costimulation. The Journal of experimental medicine 1997. PMID: 9221751
Shapiro VS, Truitt KE, Imboden JB, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Molecular and cellular biology 1997. PMID: 9199340
Huby RD, Iwashima M, Weiss A, Ley SC. ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. The Journal of cell biology 1997. PMID: 9199177
Wu J, Zhao Q, Kurosaki T, Weiss A. The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction. The Journal of experimental medicine 1997. PMID: 9151714
Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. The Journal of experimental medicine 1997. PMID: 9104812
Qian D, Weiss A. T cell antigen receptor signal transduction. Current opinion in cell biology 1997. PMID: 9069257
Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. The EMBO journal 1996. PMID: 8947048
Taylor N, Bacon KB, Smith S, Jahn T, Kadlecek TA, Uribe L, Kohn DB, Gelfand EW, Weiss A, Weinberg K. Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene. The Journal of experimental medicine 1996. PMID: 8920891
van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A. alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 1996. PMID: 8934570
Shapiro VS, Mollenauer MN, Greene WC, Weiss A. c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1. The Journal of experimental medicine 1996. PMID: 8920856
Fry AM, Lanier LL, Weiss A. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. The Journal of experimental medicine 1996. PMID: 8691146
Wu J, Motto DG, Koretzky GA, Weiss A. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 1996. PMID: 8673706
Straus DB, Chan AC, Patai B, Weiss A. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. The Journal of biological chemistry 1996. PMID: 8626636
van Oers NS, Killeen N, Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. The Journal of experimental medicine 1996. PMID: 8642247
Qian D, Mollenauer MN, Weiss A. Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. The Journal of experimental medicine 1996. PMID: 8627172
Crooks ME, Littman DR, Carter RH, Fearon DT, Weiss A, Stein PH. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Molecular and cellular biology 1995. PMID: 8524248
Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. The Journal of experimental medicine 1995. PMID: 7561679
Weiss A, Kadlecek T, Iwashima M, Chan A, Van Oers N. Molecular and genetic insights into T-cell antigen receptor signaling. Annals of the New York Academy of Sciences 1995. PMID: 7486651
Weiss A. Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling. Clinical immunology and immunopathology 1995. PMID: 7554459
Wu J, Katzav S, Weiss A. A functional T-cell receptor signaling pathway is required for p95vav activity. Molecular and cellular biology 1995. PMID: 7623828
Howe LR, Weiss A. Multiple kinases mediate T-cell-receptor signaling. Trends in biochemical sciences 1995. PMID: 7701563
Katzav S, Sutherland M, Packham G, Yi T, Weiss A. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. The Journal of biological chemistry 1994. PMID: 7798261
van Oers NS, Killeen N, Weiss A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity 1994. PMID: 7600293
Izquierdo M, Leevers SJ, Williams DH, Marshall CJ, Weiss A, Cantrell D. The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor. European journal of immunology 1994. PMID: 7925576
Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A. The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation. The EMBO journal 1994. PMID: 8076596
M Sieh, A Batzer, J Schlessinger, A Weiss. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Molecular and cellular biology 1994. PMID:
Sieh M, Batzer A, Schlessinger J, Weiss A. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Molecular and cellular biology 1994. PMID: 7516467
Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science (New York, N.Y.) 1994. PMID: 8202712
Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science (New York, N.Y.) 1994. PMID: 8202713
Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. Journal of immunology (Baltimore, Md. : 1950) 1994. PMID: 8176201
Peter H. Stein, James D. Fraser, Arthur Weiss. The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3'-Kinase. Molecular and cellular biology 1994. PMID:
P H Stein, J D Fraser, A Weiss. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase. Molecular and cellular biology 1994. PMID:
Stein PH, Fraser JD, Weiss A. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase. Molecular and cellular biology 1994. PMID: 8164687
Law CL, Sidorenko SP, Chandran KA, Draves KE, Chan AC, Weiss A, Edelhoff S, Disteche CM, Clark EA. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. The Journal of biological chemistry 1994. PMID: 8163536
van Oers NS, Teh SJ, Irving BA, Tiong J, Weiss A, Teh HS. Production and characterization of monoclonal antibodies specific for the murine T cell receptor zeta chain. Journal of immunological methods 1994. PMID: 7512608
Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science (New York, N.Y.) 1994. PMID: 7509083
Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994. PMID: 8293463
Weiss A, Iwashima M, Irving B, van Oers NS, Kadlecek TA, Straus D, Chan A. Molecular and genetic insights into T cell antigen receptor signal transduction. Advances in experimental medicine and biology 1994. PMID: 7887313
Chan AC, Desai DM, Weiss A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annual review of immunology 1994. PMID: 8011291
Fraser JD, Straus D, Weiss A. Signal transduction events leading to T-cell lymphokine gene expression. Immunology today 1993. PMID: 8363726
Desai DM, Sap J, Schlessinger J, Weiss A. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. Cell 1993. PMID: 8490965
Weiss A. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell 1993. PMID: 8477442
Irving BA, Chan AC, Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. The Journal of experimental medicine 1993. PMID: 8459204
Sieh M, Bolen JB, Weiss A. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. The EMBO journal 1993. PMID: 8428589
M. Iwashima, A. C. Chan, B. Irving, D. Straus, A. Weiss. Molecular Dissection of T-Cell Antigen Receptor Signal Transduction. Progress in Immunology Vol. VIII 1993. PMID:
Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992. PMID: 1423621
Graber M, June CH, Samelson LE, Weiss A. The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor. International immunology 1992. PMID: 1472473
Fraser JD, Weiss A. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Molecular and cellular biology 1992. PMID: 1328852
Straus DB, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 1992. PMID: 1505025
Koretzky GA, Kohmetscher MA, Kadleck T, Weiss A. Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line. Journal of immunology (Baltimore, Md. : 1950) 1992. PMID: 1380033
Chan AC, Irving BA, Weiss A. New insights into T-cell antigen receptor structure and signal transduction. Current opinion in immunology 1992. PMID: 1418701
Fraser JD, Newton ME, Weiss A. CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. The Journal of experimental medicine 1992. PMID: 1313075
Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 1992. PMID: 1531699
Weiss A, Chan AC, Iwashima M, Straus D, Irving BA. Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain. Cold Spring Harbor symposia on quantitative biology 1992. PMID: 1339649
Chan AC, Irving BA, Fraser JD, Weiss A. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proceedings of the National Academy of Sciences of the United States of America 1991. PMID: 1717999
Weiss A, Irving BA, Tan LK, Koretzky GA. Signal transduction by the T cell antigen receptor. Seminars in immunology 1991. PMID: 1839225
Weiss A, Koretzky G, Schatzman RC, Kadlecek T. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proceedings of the National Academy of Sciences of the United States of America 1991. PMID: 1712101
Tan L, Turner J, Weiss A. Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3. The Journal of experimental medicine 1991. PMID: 1827143
Graber M, Bockenstedt LK, Weiss A. Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 1826700
Koretzky GA, Picus J, Schultz T, Weiss A. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proceedings of the National Academy of Sciences of the United States of America 1991. PMID: 1672451
Weiss A, Desai D, Graber M, Picus J, Koretzky G. The regulation of T-cell antigen receptor signal transduction function. Transplantation proceedings 1991. PMID: 1990543
Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science (New York, N.Y.) 1991. PMID: 1846244
Weiss A. Molecular and genetic insights into T cell antigen receptor structure and function. Annual review of genetics 1991. PMID: 1839878
Desai DM, Newton ME, Kadlecek T, Weiss A. Stimulation of the phosphatidylinositol pathway can induce T-cell activation. Nature 1990. PMID: 2234059
Weiss A. Structure and function of the T cell antigen receptor. The Journal of clinical investigation 1990. PMID: 2211998
Koretzky GA, Picus J, Thomas ML, Weiss A. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 1990. PMID: 2164155
Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. T-lymphocyte-antigen interactions in transplant rejection. The New England journal of medicine 1990. PMID: 2405272
Desai DM, Goldsmith MA, Weiss A. A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction. International immunology 1990. PMID: 1980618
Goldsmith MA, Desai DM, Schultz T, Weiss A. Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants. The Journal of biological chemistry 1989. PMID: 2529257
Koretzky GA, Wahi M, Newton ME, Weiss A. Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines. Protein kinase C-beta is not required for several T cell functions. Journal of immunology (Baltimore, Md. : 1950) 1989. PMID: 2788192
Fraser JD, Goldsmith MA, Weiss A. Ligand-induced association between the T-cell antigen receptor and two glycoproteins. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2789381
Goldsmith MA, Bockenstedt LK, Dazin P, Weiss A. Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor. Advances in experimental medicine and biology 1989. PMID: 2573246
Morley BJ, Chin KN, Newton ME, Weiss A. The lysine residue in the membrane-spanning domain of the beta chain is necessary for cell surface expression of the T cell antigen receptor. The Journal of experimental medicine 1988. PMID: 2974063
Goldsmith MA, Dazin PF, Weiss A. At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 3263650
Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. Journal of immunology (Baltimore, Md. : 1950) 1988. PMID: 2459194
Goldsmith MA, Weiss A. New clues about T-cell antigen receptor complex function. Immunology today 1988. PMID: 3076421
John B. Imboden, Arthur Weiss. The Initiation of Human T Lymphocyte Activation (Part 1 of 2). A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 1988. PMID:
John B. Imboden, Arthur Weiss. The Initiation of Human T Lymphocyte Activation (Part 2 of 2). A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 1988. PMID:
Goldsmith MA, Weiss A. Early signal transduction by the antigen receptor without commitment to T cell activation. Science (New York, N.Y.) 1988. PMID: 3259335
John B. Imboden, Arthur Weiss. CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR. Interleukin 1988. PMID:
Goldsmith MA, Weiss A. Function of the antigen receptor in T cell activation. Advances in experimental medicine and biology 1988. PMID: 3063086
Goldsmith MA, Weiss A. Generation and analysis of a T-lymphocyte somatic mutant for studying molecular aspects of signal transduction by the antigen receptor. Annals of the New York Academy of Sciences 1988. PMID: 3073703
Bernard Manger, John Imboden, Arthur Weiss. Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation. The T-Cell Receptors 1988. PMID:
Imboden JB, Weiss A. The initiation of human T lymphocyte activation. Progress in allergy 1988. PMID: 2845427
Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain. Nature 1987. PMID: 2825032
Bockenstedt LK, Goldsmith MA, Koretzky GA, Weiss A. The activation of T lymphocytes. Rheumatic diseases clinics of North America 1987. PMID: 2963355
Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL. Functional competency of T cell antigen receptors in human thymus. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3500209
Phillips JH, Weiss A, Gemlo BT, Rayner AA, Lanier LL. Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. The Journal of experimental medicine 1987. PMID: 3500263
Imboden JB, Weiss A. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. The Biochemical journal 1987. PMID: 3426556
Lanier LL, Serafini AT, Ruitenberg JJ, Cwirla S, Federspiel NA, Phillips JH, Allison JP, Weiss A. The gamma T-cell antigen receptor. Journal of clinical immunology 1987. PMID: 3320076
Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3116093
Goldsmith MA, Weiss A. Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor. Proceedings of the National Academy of Sciences of the United States of America 1987. PMID: 3309950
Pelicci PG, Subar M, Weiss A, Dalla-Favera R, Littman DR. Molecular diversity of the human T-gamma constant region genes. Science (New York, N.Y.) 1987. PMID: 3112943
Saito T, Weiss A, Gunter KC, Shevach EM, Germain RN. Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 2955045
Lancki DW, Weiss A, Fitch FW. Requirements for triggering of lysis by cytolytic T lymphocyte clones. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 2953785
Weiss A, Shields R, Newton M, Manger B, Imboden J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3104454
Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. The Journal of experimental medicine 1987. PMID: 2435832
Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature 1987. PMID: 3104795
Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. Nature 1987. PMID: 3102973
Durand DB, Bush MR, Morgan JG, Weiss A, Crabtree GR. A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. The Journal of experimental medicine 1987. PMID: 3102668
Weiss A, Imboden JB. Cell surface molecules and early events involved in human T lymphocyte activation. Advances in immunology 1987. PMID: 2961214
Saito T, Weiss A, Miller J, Norcross MA, Germain RN. Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature 1987. PMID: 3027582
Weiss A, Imboden J, Hardy K, Stobo J. The role of the antigen receptor/T3 complex in T-cell activation. Advances in experimental medicine and biology 1987. PMID: 2957896
Lanier LL, Weiss A. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature 1986. PMID: 3491323
Lanier LL, Ruitenberg JJ, Allison JP, Weiss A. Distinct epitopes on the T cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 2428866
Weiss A, Manger B, Imboden J. Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 3088111
Manger B, Hardy KJ, Weiss A, Stobo JD. Differential effect of cyclosporin A on activation signaling in human T cell lines. The Journal of clinical investigation 1986. PMID: 2422208
Manger B, Weiss A, Hardy KJ, Stobo JD. A transferrin receptor antibody represents one signal for the induction of IL 2 production by a human T cell line. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 3001178
Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J. The role of the T3/antigen receptor complex in T-cell activation. Annual review of immunology 1986. PMID: 2939858
Manger B, Weiss A, Weyand C, Goronzy J, Stobo JD. T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3934263
Imboden JB, Weiss A, Stobo JD. Transmembrane signalling by the T3-antigen receptor complex. Immunology today 1985. PMID: 25291003
Ohashi PS, Mak TW, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, Terhorst C, Stobo JD, Weiss A. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature 1985. PMID: 4033759
Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3918105
Imboden JB, Weiss A, Stobo JD. The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3871211
Weiss A, Stobo JD. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. The Journal of experimental medicine 1984. PMID: 6208306
Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6234599
Weiss A, Wiskocil RL, Stobo JD. The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level. Journal of immunology (Baltimore, Md. : 1950) 1984. PMID: 6327821
Weiss A, Imboden J, Wiskocil R, Stobo J. The role of T3 in the activation of human T cells. Journal of clinical immunology 1984. PMID: 6203926
Weiss A, MacDonald HR, Cerottini JC, Brunner KT. Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction. Journal of immunology (Baltimore, Md. : 1950) 1981. PMID: 6450244
Weiss A, Brunner KT, MacDonald HR, Cerottini JC. Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens. The Journal of experimental medicine 1980. PMID: 6159445
Stuart FP, McKearn TJ, Weiss A, Fitch FW. Suppression of rat renal allograft rejection by antigen and antibody. Immunological reviews 1980. PMID: 6989746
McKearn TJ, Weiss A, Stuart FP, Fitch FW. Selective suppression of humoral and cell-mediated immune responses to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines. Transplantation proceedings 1979. PMID: 377725
Weiss A, Stuart FP, Fitch FW. Immune reactivity of cells from long-term rat renal allograft survivors. Transplantation 1978. PMID: 151955
Weiss A, Fitch FW, McKearn TJ, Stuart FP. Immunological memory is regulated in the enhanced rat renal allograft recipient. Nature 1978. PMID: 351414
Fitch FW, Weiss A, McKearn TJ, Stuart FP. Graft enhancement and antiidiotypic antibody. Lymphocytes from long-term rat renal allograft recipients have normal responsiveness in vitro. Transplantation proceedings 1978. PMID: 79259
Weiss A, Fitch FW. Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen. Journal of immunology (Baltimore, Md. : 1950) 1978. PMID: 621383
Weiss A, Stuart FP, Fitch FW. Absence of immunologic memory in recipients of enhanced renal allografts. Surgical forum 1978. PMID: 162608
McKearn TJ, Sarmiento M, Weiss A, Stuart FP, Fitch FW. Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies. Current topics in microbiology and immunology 1978. PMID: 308442
Weiss A, Fitch FW. Macrophages suppress CTL generation in rat mixed leukocyte cultures. Journal of immunology (Baltimore, Md. : 1950) 1977. PMID: 142114
Weiss A. Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum. Journal of immunology (Baltimore, Md. : 1950) 1977. PMID: 139446
Edidin M, Weiss A. Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. Proceedings of the National Academy of Sciences of the United States of America 1972. PMID: 4560687