Hailyn Nielsen, MD, PhD

Education
Fellowship, 05/2022 - Rheumatology, University of California - San Francisco
Residency, 06/2018 - Internal Medicine, University of California - San Francisco
MD, 05/2015 - , Washington University in St. Louis, School of Medicine
PhD, 05/2015 - Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, School of Medicine
BS, 05/2005 - Microbiology, University of Iowa
Honors and Awards
  • Scientist Development Award, Rheumatology Research Foundation, 2022-2025
  • Predoctoral Fellowship, American Heart Association Midwest Affiliate, 2010-2011
Publications

  1. Nielsen HV, Yang L, Mueller JL, Ritter AJ, Hiwa R, Proekt I, Rackaityte E, Aylard D, Gupta M, Scharer CD, Anderson MS, Au-Yeung BB, Zikherman J. Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice. Nature communications 2025. PMID: 39824797


  2. Brooks JF, Riggs J, Mueller JL, Mathenge R, Wholey WY, Meyer AR, Yoda ST, Vykunta VS, Nielsen HV, Cheng W, Zikherman J. Molecular basis for potent B cell responses to antigen displayed on particles of viral size. Nature immunology 2023. PMID: 37653247


  3. Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J. NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35174510


  4. Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J. NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity. JCI insight 2021. PMID: 34343134


  5. O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ. Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiology spectrum 2016. PMID: 26999391


  6. Korte-Berwanger M, Sakinc T, Kline K, Nielsen HV, Hultgren S, Gatermann SG. Significance of the D-serine-deaminase and D-serine metabolism of Staphylococcus saprophyticus for virulence. Infection and immunity 2013. PMID: 24082071


  7. Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. Journal of bacteriology 2013. PMID: 23913319


  8. Watson ME, Nielsen HV, Hultgren SJ, Caparon MG. Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infection and immunity 2013. PMID: 23460515


  9. Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. mBio 2012. PMID: 22829678


  10. Maddalo G, Chovanec P, Stenberg-Bruzell F, Nielsen HV, Jensen-Seaman MI, Ilag LL, Kline KA, Daley DO. A reference map of the membrane proteome of Enterococcus faecalis. Proteomics 2011. PMID: 21800426


  11. Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ. Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infection and immunity 2010. PMID: 20176795


  12. Ingersoll MA, Kline KA, Nielsen HV, Hultgren SJ. G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cellular microbiology 2008. PMID: 18754853