Hailyn Nielsen, MD, PhD

Assistant Professor

I am a physician-scientist in the UCSF Division of Rheumatology. I keep a general rheumatology clinic at the Parnassus campus where I treat patients with autoimmune diseases. Additionally, I carry out post-doctoral research in the laboratory of Dr. Julie Zikherman also in the Division of Rheumatology. Broadly, my research involves using mouse models of autoimmunity to dissect molecular mechanisms of immune tolerance.
Fellowship, 05/2022 - Rheumatology, University of California - San Francisco
Residency, 06/2018 - Internal Medicine, University of California - San Francisco
MD, 05/2015 - , Washington University in St. Louis, School of Medicine
PhD, 05/2015 - Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, School of Medicine
BS, 05/2005 - Microbiology, University of Iowa
Honors and Awards
  • Scientist Development Award, Rheumatology Research Foundation, 2022-2025
  • Predoctoral Fellowship, American Heart Association Midwest Affiliate, 2010-2011
  1. Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J. NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance. 2022. PMID: 35174510

  2. Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J. NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity. 2021. PMID: 34343134

  3. O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ. Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. 2016. PMID: 26999391

  4. Korte-Berwanger M, Sakinc T, Kline K, Nielsen HV, Hultgren S, Gatermann SG. Significance of the D-serine-deaminase and D-serine metabolism of Staphylococcus saprophyticus for virulence. 2013. PMID: 24082071

  5. Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. 2013. PMID: 23913319

  6. Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. 2012. PMID: 22829678

  7. Maddalo G, Chovanec P, Stenberg-Bruzell F, Nielsen HV, Jensen-Seaman MI, Ilag LL, Kline KA, Daley DO. A reference map of the membrane proteome of Enterococcus faecalis. 2011. PMID: 21800426

  8. Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ. Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. 2010. PMID: 20176795