Judith Ashouri Sinha, MD

Assistant Professor

Rheumatoid arthritis (RA) afflicts millions globally, causing significant joint deformity, pain, and functional disability. RA is without cure and its cause is unknown, but CD4 T cells—immune cells widely accepted to play a key role in RA pathogenesis—from patients with RA become activated by proteins through their T cell receptor (called “antigen-specific T cells”) and cause arthritis. Dr. Ashouri’s research uses a unique tool to identify and characterize these antigen-activated T cells in both a mouse model of RA and human RA. Elucidating the contribution of these pathogenic CD4 T cells to arthritis development in RA holds promise for the discovery of improved therapeutic targets.
Education
Fellowship, 06/2014 - Rheumatology, University of California, San Francisco
Residency, 06/2011 - Internal Medicine, Stanford University Hospital & Clinics
MD, 06/2008 - , University of California, San Francisco
Honors and Awards
  • Arthritis National Research Foundation Scholar, Arthritis National Research Foundation, 2018-2020
  • K Bridge Award, Rheumatology Research Foundation, 2017-2018
  • Bechtel Junior Faculty Award, UCSF Division of Rheumatology, 2016-2019
  • Scientist Development Award, Rheumatology Research Foundation, 2012-2015
Publications
  1. Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, Carvidi A, Krueger M, Gross A, Criswell LA, Ashouri JF, Sirota M. Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis. 2021. PMID: 34177888


  2. Shams S, Martinez JM, Dawson JRD, Flores J, Gabriel M, Garcia G, Guevara A, Murray K, Pacifici N, Vargas MV, Voelker T, Hell JW, Ashouri JF. The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions. 2021. PMID: 34122106


  3. Jiang Y, Jarr K, Layton C, Gardner CD, Ashouri JF, Abreu MT, Sinha SR. Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases. 2021. PMID: 33801883


  4. Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. 2020. PMID: 33294857


  5. Jadhav P, Jiang Y, Jarr K, Layton C, Ashouri JF, Sinha SR. Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases. 2020. PMID: 32698454


  6. Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. 2019. PMID: 31455730


  7. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Volume 111 of Issue 35. 2014. PMID: 25136127


  8. Ashouri JF, Davis JL, Farkas A, Durack JC, Ramachandran R, Dall'Era M. A young woman with systemic lupus erythematosus and extensive mesenteric vasculitis involving small and medium vessels. 2012. PMID: 22933330


  9. Ashouri JF, Daikh DI. Rheumatic manifestations of cancer. 2011. PMID: 22075194


  10. Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. 2008. PMID: 18281687


  11. Palaszynski KM, Loo KK, Ashouri JF, Liu HB, Voskuhl RR. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. 2004. PMID: 14698857


  12. Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB, Voskuhl RR. Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. 2003. PMID: 14662901


  13. Angelilli ML, Fischer H, Delaney-Black V, Rubinstein M, Ager JW, Sokol RJ. History of in utero cocaine exposure in language-delayed children. 1994. PMID: 8001318


  14. Breithardt G, Wichter T, Fetsch T, Seifert T, Borggrefe M, Shenasa M, Reinhardt L. The signal-averaged ECG: time-domain analysis. 1993. PMID: 8223752