Julie Zikherman, MD

Publications

  1. Wholey WY, Meyer AR, Yoda ST, Chackerian B, Zikherman J, Cheng W. Mechanisms of neutralizing antibody response probed using synthetic virus-like structures. bioRxiv : the preprint server for biology 2023. PMID: 36865112


  2. Wholey WY, Meyer AR, Yoda ST, Mueller JL, Mathenge R, Chackerian B, Zikherman J, Cheng W. An integrated signaling threshold initiates IgG response towards virus-like immunogens. bioRxiv : the preprint server for biology 2024. PMID: 38469153


  3. Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu DJ, Zamecnik CR, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, DeRisi JL. Validation of a murine proteome-wide phage display library for identification of autoantibody specificities. JCI insight 2023. PMID: 37934865


  4. Brooks JF, Riggs J, Mueller JL, Mathenge R, Wholey WY, Meyer AR, Yoda ST, Vykunta VS, Nielsen HV, Cheng W, Zikherman J. Molecular basis for potent B cell responses to antigen displayed on particles of viral size. Nature immunology 2023. PMID: 37653247


  5. Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik C, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, DeRisi JL. Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities. bioRxiv : the preprint server for biology 2023. PMID: 37066405


  6. Brooks JF, Riggs J, Mueller JL, Mathenge R, Wholey WY, Yoda ST, Vykunta V, Cheng W, Zikherman J. Molecular basis for potent B cell responses to antigen displayed on particles of viral size. bioRxiv : the preprint server for biology 2023. PMID: 36824873


  7. Bending D, Zikherman J. Nr4a nuclear receptors: markers and modulators of antigen receptor signaling. Current opinion in immunology 2023. PMID: 36764055


  8. Pelanda R, Zikherman J. Many Achilles' heels of B and T cell tolerance. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35301733


  9. Rizzuto G, Brooks JF, Tuomivaara ST, McIntyre TI, Ma S, Rideaux D, Zikherman J, Fisher SJ, Erlebacher A. Establishment of fetomaternal tolerance through glycan-mediated B cell suppression. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35236989


  10. Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J. NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35174510


  11. Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35139352


  12. Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nature chemical biology 2021. PMID: 34556859


  13. Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J. NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity. JCI insight 2021. PMID: 34343134


  14. Brooks JF, Tan C, Mueller JL, Hibiya K, Hiwa R, Vykunta V, Zikherman J. Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses. Cell reports 2021. PMID: 34469720


  15. Brooks JF, Zikherman J. The BAFFling persistence of memory B cells. The Journal of experimental medicine 2021. PMID: 33185684


  16. Tan C, Hiwa R, Mueller JL, Vykunta V, Hibiya K, Noviski M, Huizar J, Brooks JF, Garcia J, Heyn C, Li Z, Marson A, Zikherman J. NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. Nature immunology 2020. PMID: 32868928


  17. Wholey WY, Mueller JL, Tan C, Brooks JF, Zikherman J, Cheng W. Synthetic liposomal mimics of biological viruses for the study of immune responses to infection and vaccination. Bioconjugate chemistry 2020. PMID: 31940172


  18. Tan C, Noviski M, Huizar J, Zikherman J. Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance. Immunological reviews 2019. PMID: 31631352


  19. Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V. Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis. Journal of the American Heart Association 2019. PMID: 31538835


  20. Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proceedings of the National Academy of Sciences of the United States of America 2019. PMID: 31455730


  21. Noviski M, Tan C, Huizar J, Vykunta V, Mueller JL, Zikherman J. Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens. Journal of immunology (Baltimore, Md. : 1950) 2019. PMID: 31167773


  22. Zikherman J. GC B cells 'AKT' to blunt BCR signaling. Nature immunology 2019. PMID: 31011188


  23. Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J. Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery. Journal of immunology (Baltimore, Md. : 1950) 2019. PMID: 30962292


  24. Noviski M, Zikherman J. Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance. Current opinion in immunology 2018. PMID: 30292928


  25. Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Volume 7. 2018. PMID: 29521626


  26. Huizar J, Tan C, Noviski M, Mueller JL, Zikherman J. Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells. Volume 1 of Issue 9. 2017. PMID: 29152611


  27. Zikherman J, Lowell CA. B cell autoimmunity at the extremes. Volume 18 of Issue 10. 2017. PMID: 28926534


  28. Myers DR, Zikherman J, Roose JP. Tonic Signals: Why Do Lymphocytes Bother? Volume 38 of Issue 11. 2017. PMID: 28754596


  29. Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Volume 19 of Issue 8. 2017. PMID: 28538176


  30. Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J. IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level. Volume 198 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2017. PMID: 28159902


  31. Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J. An extracatalytic function of CD45 in B cells is mediated by CD22. Volume 112 of Issue 47. Proceedings of the National Academy of Sciences of the United States of America 2015. PMID: 26561584


  32. Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. Volume 194 of Issue 8. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 25769918


  33. Mueller J, Matloubian M, Zikherman J. Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center. Volume 194 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 25725108


  34. Zikherman J, Au-Yeung B. The role of T cell receptor signaling thresholds in guiding T cell fate decisions. Volume 33. Current opinion in immunology 2015. PMID: 25660212


  35. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Volume 111 of Issue 35. Proceedings of the National Academy of Sciences of the United States of America 2014. PMID: 25136127


  36. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Volume 15 of Issue 7. 2014. PMID: 24908390


  37. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Volume 34 of Issue 8. 2014. PMID: 24515435


  39. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. Volume 190 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2013. PMID: 23396948


  40. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Volume 6 of Issue 256. 2013. PMID: 23281368


  41. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Volume 489 of Issue 7414. 2012. PMID: 22902503


  42. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Volume 109 of Issue 1. Proceedings of the National Academy of Sciences of the United States of America 2011. PMID: 22135465


  43. Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. Volume 121 of Issue 12. The Journal of clinical investigation 2011. PMID: 22080861


  44. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Volume 32 of Issue 3. 2010. PMID: 20346773


  45. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Volume 2 of Issue 66. 2009. PMID: 19366993


  46. Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. Volume 182 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 19299707


  47. Hermiston ML, Zikherman J, Zhu JW. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Volume 228 of Issue 1. 2009. PMID: 19290935


  48. Zikherman J, Weiss A. Antigen receptor signaling in the rheumatic diseases. Volume 11 of Issue 1. 2009. PMID: 19232064


  49. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Volume 136 of Issue 2. 2009. PMID: 19167334


  50. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Volume 106 of Issue 2. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19129486


  51. Zikherman J, Weiss A. Alternative splicing of CD45: the tip of the iceberg. Volume 29 of Issue 6. 2008. PMID: 19100695


  52. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Volume 106 of Issue 2. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19098101