Kristen Mengwasser, MD, PhD

Education
Internal Medicine Residency, - Medicine, Brigham and Women's Hospital
MD, - Medicine, Harvard Medical School/MIT
BA, - Biochemical Sciences, Harvard University
PhD, - Genetics, Harvard University
Rheumatology Fellowship, - Rheumatology, UCSF
MPhil, - Biochemistry, University of Cambridge
Honors and Awards
  • Early Career Investigator Award, SPARTAN Network, 2025-2027
  • ZSFG Human Biospecimen Pipeline Development Award - shared with Dr. Diana Alba, Office of Collaborative Research, 2025-2026
  • SAA/Bruckel Early Career Investigator Award, SAA, 2025-2026
  • Catalyst Award, UCSF Catalyst Program, 2025
  • Distinguished Fellow Award, American College of Rheumatology, 2025
  • Postdoctoral Research Fellowship and Leadership Award, A.P. Giannini Foundation, 2024-2027
  • Mentored Fellowship Award, SPARTAN Network, 2024-2025
  • Diversity in Bench Sciences Award, UCSF Department of Medicine, 2022-2026
Publications

  1. Oreskovic E, Wheeler EC, Mengwasser KE, Fujimura E, Martin TD, Tothova Z, Elledge SJ. Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1. Volume 119 of Issue 7. Proceedings of the National Academy of Sciences of the United States of America 2022. PMID: 35149558


  2. Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C. Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Volume 28 of Issue 13. Cell reports 2019. PMID: 31553912


  3. Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Volume 73 of Issue 5. Molecular cell 2019. PMID: 30686591


  4. Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Volume 30 of Issue 24. Genes & development 2016. PMID: 28087713


  5. Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Volume 155 of Issue 4. Cell 2013. PMID: 24183448


  6. Mengwasser KE, Bryant CE, Gay NJ, Gangloff M. LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding. Volume 76 of Issue 2. Protein expression and purification 2010. PMID: 21130168


  7. Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Volume 105 of Issue 6. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18227510


  8. Mengwasser KE, Bush LA, Shih P, Cantwell AM, Di Cera E. Hirudin binding reveals key determinants of thrombin allostery. Volume 280 of Issue 29. The Journal of biological chemistry 2005. PMID: 15923186