Mary Nakamura, MD

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, 1994 - Rheumatology, University of California, San Francisco
Fellowship, 1991 - Rheumatology, Johns Hopkins University
Residency, 1989 - Internal Medicine, University of California, San Francisco
MD, 1986 - School of Medicine, Yale University
BA, 1981 - Biology, Swarthmore College
Honors and Awards
  • Director PREMIER: Precision Medicine in Rheumtology p30 Center, UCSF, 2020
  • Associate Director PREMIER: Precision Medicine in Rheumtology p30 Center, UCSF, 2016-2020
  • Excellence in Teaching Award in medical education, The Haile Debas Academy of Medical Educators, UCSF, 2015
  • Henry Kunkel Young Investigator Award, American College of Rheumatology, 2005
  • Ira M. Goldstein Award for Outstanding Teaching in Rheumatology, UCSF, 2004
  • Presidential Early Career Award, President of US, 2000
  • VA Career Development Award, VA, 1998
  • Physician Scientist Development Award, ACR, 1993
  • Jeffrey Weingarten Award for Housestaff, UCSF, 1989
  • J.M. Glasgow Memorial AMWA scholastic citation, Yale Medical School, 1986
  • Louis G. Welt Prize for medical school thesis, Yale Medical School, 1986
Websites
Publications

  1. Adams C, Nair N, Plant D, Verstappen SMM, Quach HL, Quach DL, Carvidi A, Nititham J, Nakamura M, Graf J, Barton A, Criswell LA, Barcellos LF. Identification of cell-specific differential DNA methylation associated with methotrexate treatment response in rheumatoid arthritis. Arthritis & rheumatology (Hoboken, N.J.) 2023. PMID: 36716083


  2. Pawar N, Taylor KE, Yang M, Deepak P, Kim W, Paley MA, Matloubian M, Carvidi A, Ciorba MA, Demissie E, El-Qunni A, Huang K, Kinnett B, McMorrow LE, Paez D, Poole M, Rose A, Schriefer RE, Kim AHJ, Nakamura M, Katz P, Gensler LS. Sleep disturbance improves with SARS-COV2 vaccinations in patients with Chronic Inflammatory Disease. Arthritis care & research 2022. PMID: 36479599


  3. Greene SE, Huang Y, Kim W, Liebeskind MJ, Chandrasekaran V, Liu Z, Deepak P, Paley MA, Lew D, Yang M, Matloubian M, Gensler LS, Nakamura MC, O'Hallaran JA, Presti RM, Whelan SPJ, Buchser WJ, Kim AHJ, Weil GJ. A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination. Journal of clinical virology plus 2023. PMID: 36644774


  4. Clark D, Doelling J, Hu D, Miclau T, Nakamura M, Marcucio R. Age-related decrease in periostin expression may be associated with attenuated fracture healing in old mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022. PMID: 36058631


  5. Yang MM, Taylor KE, Paez D, Carividi A, Demissie E, Pawar N, El-Qunni AA, McMorrow LE, Schriefer RE, Huang K, Kinnett B, Klebert M, Haile A, O'Halloran JA, Presti RM, Kim W, Ellebedy AH, Ciorba MA, Paley MA, Deepak P, Kim AHJ, Katz P, Matloubian M, Nakamura M, Gensler LS. Reactogenicity of the mRNA SARS-CoV-2 Vaccines Associates with Immunogenicity in Patients with Autoimmune and Inflammatory Disease. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35412029


  6. Patterson SL, Sun S, Rychkov D, Katz P, Tsitsiklis A, Nakamura MC, Serpa PH, Langelier CR, Sirota M. Physical Activity Associates with Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis. The Journal of rheumatology 2022. PMID: 35777820


  7. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC. Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122]. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2022. PMID: 35241401


  8. Kim AHJ, Nakamura MC. COVID-19 Breakthrough Infection Among Immunocompromised Persons. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2021. PMID: 34962552


  9. Somebang K, Rudolph J, Imhof I, Li L, Niemi EC, Shigenaga J, Tran H, Gill TM, Lo I, Zabel BA, Schmajuk G, Wipke BT, Gyoneva S, Jandreski L, Craft M, Benedetto G, Plowey ED, Charo I, Campbell J, Ye CJ, Panter SS, Nakamura MC, Eckalbar W, Hsieh CL. CCR2 deficiency alters activation of microglia subsets in traumatic brain injury. Cell reports 2021. PMID: 34551293


  10. Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, Demissie EG, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Pawar N, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Akuse S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ. Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study. Annals of internal medicine 2021. PMID: 34461029


  11. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC. ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages. Bone 2021. PMID: 34311122


  12. Fraenkel L, Bathon JM, England BR, St Clair EW, Arayssi T, Carandang K, Deane KD, Genovese M, Huston KK, Kerr G, Kremer J, Nakamura MC, Russell LA, Singh JA, Smith BJ, Sparks JA, Venkatachalam S, Weinblatt ME, Al-Gibbawi M, Baker JF, Barbour KE, Barton JL, Cappelli L, Chamseddine F, George M, Johnson SR, Kahale L, Karam BS, Khamis AM, Navarro-Millán I, Mirza R, Schwab P, Singh N, Turgunbaev M, Turner AS, Yaacoub S, Akl EA. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis care & research 2021. PMID: 34101387


  13. Fraenkel L, Bathon JM, England BR, St Clair EW, Arayssi T, Carandang K, Deane KD, Genovese M, Huston KK, Kerr G, Kremer J, Nakamura MC, Russell LA, Singh JA, Smith BJ, Sparks JA, Venkatachalam S, Weinblatt ME, Al-Gibbawi M, Baker JF, Barbour KE, Barton JL, Cappelli L, Chamseddine F, George M, Johnson SR, Kahale L, Karam BS, Khamis AM, Navarro-Millán I, Mirza R, Schwab P, Singh N, Turgunbaev M, Turner AS, Yaacoub S, Akl EA. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.) 2021. PMID: 34101376


  14. Vallania F, Zisman L, Macaubas C, Hung SC, Rajasekaran N, Mason S, Graf J, Nakamura M, Mellins ED, Khatri P. Multicohort Analysis Identifies Monocyte Gene Signatures to Accurately Monitor Subset-Specific Changes in Human Diseases. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2021. PMID: 34054824


  15. Clark D, Halpern B, Miclau T, Nakamura M, Kapila Y, Marcucio R. The Contribution of Macrophages in Old Mice to Periodontal Disease. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 2021. PMID: 33906501


  16. . Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2. medRxiv : the preprint server for health sciences 2021. PMID: 33851176


  17. . Targeting Nerve Growth Factor for Pain Management in Osteoarthritis-Clinical Efficacy and Safety. Rheumatic diseases clinics of North America 2021. PMID: 33781489


  18. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. The Journal of clinical investigation 2020. PMID: 33290276


  19. Vasudevan S, Vásquez JJ, Chen W, Aguilar-Rodriguez B, Niemi EC, Zeng S, Tamaki W, Nakamura MC, Arjomandi M. Lower PDL1/2 and AXL Expression on Lung Myeloid Cells Suggests Inflammatory Bias in Smoking and COPD. American journal of respiratory cell and molecular biology 2020. PMID: 32915645


  20. Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA. Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation. PloS one 2020. PMID: 33021986


  21. Razani B, Whang MI, Kim FS, Nakamura MC, Sun X, Advincula R, Turnbaugh JA, Pendse M, Tanbun P, Achacoso P, Turnbaugh PJ, Malynn BA, Ma A. Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation. Nature immunology 2020. PMID: 32205880


  22. Clark D, Brazina S, Yang F, Hu D, Hsieh CL, Niemi EC, Miclau T, Nakamura MC, Marcucio R. Age-related changes to macrophages are detrimental to fracture healing in mice. Aging cell 2020. PMID: 32096907


  23. Wang L, Roth T, Nakamura MC, Nissenson RA. Female-Specific Role of Progranulin to Suppress Bone Formation. Endocrinology 2019. PMID: 31237618


  24. Nakamura MC. Osteoimmunology: entwined regulation of integrated systems. Seminars in immunopathology 2019. PMID: 31654179


  25. Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC. NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI insight 2018. PMID: 30429363


  26. Clark D, Nakamura M, Miclau T, Marcucio R. Effects of Aging on Fracture Healing. Volume 15 of Issue 6. 2017. PMID: 29143915


  27. Humphrey MB, Nakamura MC. A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts. Volume 51 of Issue 1. 2016. PMID: 26573914


  28. Kim CC, Nakamura MC, Hsieh CL. Brain trauma elicits non-canonical macrophage activation states. Volume 13 of Issue 1. 2016. PMID: 27220367


  29. Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. Volume 35 of Issue 8. 2015. PMID: 25716838


  30. Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC. CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. Volume 31 of Issue 20. 2014. PMID: 24806994


  31. Charles JF, Nakamura MC. Bone and the innate immune system. Volume 12 of Issue 1. 2014. PMID: 24500569


  32. Nakamura MC. CIITA: a master regulator of adaptive immunity shows its innate side in the bone. Volume 29 of Issue 2. 2014. PMID: 24343972


  33. Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari MA. Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke. Volume 3 of Issue 4. 2013. PMID: 24380032


  34. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Volume 43 of Issue 8. 2013. PMID: 23630120


  35. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. Volume 122 of Issue 12. The Journal of clinical investigation 2012. PMID: 23114597


  36. Chitu V, Nacu V, Charles JF, Henne WM, McMahon HT, Nandi S, Ketchum H, Harris R, Nakamura MC, Stanley ER. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Volume 120 of Issue 15. Blood 2012. PMID: 22923495


  37. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Volume 12 of Issue 12. 2011. PMID: 22019834


  38. Baker-LePain JC, Nakamura MC, Lane NE. Effects of inflammation on bone: an update. Volume 23 of Issue 4. 2011. PMID: 21532485


  39. Baker-LePain JC, Nakamura MC, Shepherd J, von Scheven E. Assessment of bone remodelling in childhood-onset systemic lupus erythematosus. Volume 50 of Issue 3. 2010. PMID: 21098573


  40. Adapala NS, Barbe MF, Langdon WY, Nakamura MC, Tsygankov AY, Sanjay A. The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. Volume 285 of Issue 47. The Journal of biological chemistry 2010. PMID: 20851882


  41. Baker-LePain JC, Stone DH, Mattis AN, Nakamura MC, Fye KH. Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics. Volume 62 of Issue 11. 2010. PMID: 20662047


  42. Xing Z, Lu C, Hu D, Yu YY, Wang X, Colnot C, Nakamura M, Wu Y, Miclau T, Marcucio RS. Multiple roles for CCR2 during fracture healing. Volume 3 of Issue 7-8. 2010. PMID: 20354109


  43. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Volume 107 of Issue 8. Proceedings of the National Academy of Sciences of the United States of America 2010. PMID: 20133674


  44. Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB. IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. Volume 183 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 19625651


  45. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Volume 109 of Issue 4. 2009. PMID: 19302484


  47. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Volume 76 of Issue 6. 2008. PMID: 18391000


  48. Wu Y, Humphrey MB, Nakamura MC. Osteoclasts - the innate immune cells of the bone. Volume 41 of Issue 3. 2008. PMID: 18365831


  49. Wu Y, Torchia J, Yao W, Lane NE, Lanier LL, Nakamura MC, Humphrey MB. Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency. Volume 2 of Issue 7. PloS one 2007. PMID: 17611621


  50. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. Volume 177 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16887962


  51. Humphrey MB, Lanier LL, Nakamura MC. Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Volume 208. 2005. PMID: 16313340


  52. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Volume 21 of Issue 2. 2005. PMID: 16418779


  53. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. Volume 202 of Issue 7. 2005. PMID: 16203866


  54. Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. Volume 20 of Issue 1. 2004. PMID: 15619670


  55. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Volume 101 of Issue 16. Proceedings of the National Academy of Sciences of the United States of America 2004. PMID: 15073337


  56. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier LL, Nakamura MC. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. Volume 19 of Issue 2. 2003. PMID: 14969392


  57. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Volume 171 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 14662855