Mehrdad Matloubian, MD, PhD
I have a general interest in mechanisms of immune mediated diseases and approaches for a better understanding of the molecular bases of such processes. The goal is to provided therapeutic for treatment of autoimmune and inflammatory diseases through a better understanding of the involved pathways.
Postdoctoral Studies, - Graduate Division, University of California, San Francisco
- A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression.
- The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.
- miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
- Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells.
- Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation.
- 522 Sex-Specific Responses of the Corticotropin-Releasing Factor System in a Mouse Model of Inflammatory Bowel Disease.
- Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.
- A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
- 16 MIR-17~92 promotes T follicular helper cell differentiation and represses subset-inappropriate gene expression.
- 91 Homotypic T–T synapses promote collective CD8+ T cell differentiation through exchange of IFN gamma.
- The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
- B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.
- IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
- MicroRNA function in NK-cell biology.
- Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
- Th1 cell induction in lymph nodes according to a red-blue chemokine map.
- Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.
- MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.
- Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation.
- Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
- S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress.
- Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
- Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
- CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
- Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
- Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
- Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
- Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.
- Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection.
- A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
- A role for perforin in downregulating T-cell responses during chronic viral infection.
- Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
- Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
- Mechanisms of CTL-mediated cytoxicity.
- Molecular pathways of CTL-mediated cytotoxicity.
- Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.
- Bone marrow is a major site of long-term antibody production after acute viral infection.
- Cell-mediated cytotoxicity in perforin-less mice.
- CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
- Immune function in mice lacking the perforin gene.
- Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus.
- Molecular basis of organ-specific selection of viral variants during chronic infection.
- Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.
- Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus.