Mehrdad Matloubian, MD, PhD

Professor

I have a general interest in mechanisms of immune mediated diseases and approaches for a better understanding of the molecular bases of such processes. The goal is to provided therapeutic for treatment of autoimmune and inflammatory diseases through a better understanding of the involved pathways.
Education
Postdoctoral Studies, - Graduate Division, University of California, San Francisco
Websites
Publications
  1. A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression.
  2. The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.
  3. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
  4. Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells.
  5. Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation.
  6. 522 Sex-Specific Responses of the Corticotropin-Releasing Factor System in a Mouse Model of Inflammatory Bowel Disease.
  7. Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.
  8. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
  9. 16 MIR-17~92 promotes T follicular helper cell differentiation and represses subset-inappropriate gene expression.
  10. 91 Homotypic T–T synapses promote collective CD8+ T cell differentiation through exchange of IFN gamma.
  11. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
  12. B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.
  13. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
  14. MicroRNA function in NK-cell biology.
  15. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
  16. Th1 cell induction in lymph nodes according to a red-blue chemokine map.
  17. Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.
  18. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.
  19. Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation.
  20. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
  21. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress.
  22. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
  23. Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
  24. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
  25. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
  26. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
  27. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
  28. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.
  29. Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection.
  30. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
  31. A role for perforin in downregulating T-cell responses during chronic viral infection.
  32. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
  33. Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
  34. Mechanisms of CTL-mediated cytoxicity.
  35. Molecular pathways of CTL-mediated cytotoxicity.
  36. Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.
  37. Bone marrow is a major site of long-term antibody production after acute viral infection.
  38. Cell-mediated cytotoxicity in perforin-less mice.
  39. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
  40. Immune function in mice lacking the perforin gene.
  41. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus.
  42. Molecular basis of organ-specific selection of viral variants during chronic infection.
  43. Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.
  44. Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus.