Renuka Nayak, MD, PhD

Assistant Professor

Dr. Renuka Nayak, MD, PhD, is a physician-scientist dedicated to advancing the care and treatment of patients with rheumatologic conditions such as rheumatoid arthritis, lupus, psoriatic arthritis, and other autoimmune diseases. She uses her unique backgrounds in Biology, Computer Science, and Clinical Rheumatology to investigate the role of the human gut microbiome in the treatment of rheumatoid arthritis. She uses an innovative combination of patient specimens, microbiology, next generation sequencing, and gnotobiotic mouse models to better understand how our microbiome, which many consider our "second genome," influences health and disease.
Education
2022 - Diversity, Equity, and Inclusion Champion Training, University of California
2017 - Rheumatology, UCSF
2014 - Internal Medicine, UCSF
MD, PhD, 2012 - Genomics, University of Pennsylvania
BA, 2004 - Biology, Swarthmore College
BA, 2004 - Computer Science, Swarthmore College
Publications
  1. Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, Upadhyay V, Pollard KS, Lynch SV, Turnbaugh PJ. Human gut bacterial metabolism drives Th17 activation and colitis. 2021. PMID: 34822777


  2. Lam KN, Spanogiannopoulos P, Soto-Perez P, Alexander M, Nalley MJ, Bisanz JE, Nayak RR, Weakley AM, Yu FB, Turnbaugh PJ. Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome. 2021. PMID: 34731631


  3. Artacho A, Isaac S, Nayak R, Flor-Duro A, Alexander M, Koo I, Manasson J, Smith PB, Rosenthal P, Homsi Y, Gulko P, Pons J, Puchades-Carrasco L, Izmirly P, Patterson A, Abramson SB, Pineda-Lucena A, Turnbaugh PJ, Ubeda C, Scher JU. The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis. 2021. PMID: 33314800


  4. Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ. Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. 2021. PMID: 33440172


  5. Scher JU, Nayak RR, Ubeda C, Turnbaugh PJ, Abramson SB. Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response. 2020. PMID: 32157196


  6. Mok A, Solomon O, Nayak RR, Coit P, Quach HL, Nititham J, Sawalha AH, Barcellos LF, Criswell LA, Chung SA. Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses. Volume 3 of Issue 1. 2016. PMID: 28074145


  7. Nayak RR, Turnbaugh PJ. Mirror, mirror on the wall: which microbiomes will help heal them all? Volume 14. 2016. PMID: 27146150


  8. Nayak RR, Bernal WE, Lee JW, Kearns MJ, Cheung VG. Stress-induced changes in gene interactions in human cells. Volume 42 of Issue 3. 2013. PMID: 24170811


  9. Cheung VG, Nayak RR, Wang IX, Elwyn S, Cousins SM, Morley M, Spielman RS. Polymorphic cis- and trans-regulation of human gene expression. Volume 8 of Issue 9. 2010. PMID: 20856902


  10. Dombroski BA, Nayak RR, Ewens KG, Ankener W, Cheung VG, Spielman RS. Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells. Volume 86 of Issue 5. 2010. PMID: 20398888


  11. Nayak RR, Kearns M, Spielman RS, Cheung VG. Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. Volume 19 of Issue 11. 2009. PMID: 19797678