William Seaman, MD

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
MD, 1969 - Medicine, Harvard Medical School
Websites
Publications

  1. Craft JE, Crow MK, Diamond B, Elkon KB, Flood J, Fox DA, Gabriel SE, Gilkeson GS, Hahn BH, Hardin JA, Koopman WJ, Lockshin MD, Salmon JE, Seaman WE, Sergent JS, Uknis AB, Weinblatt ME, Wofsy D. Georgia Abortion Law and our Commitment to Patients. Arthritis & rheumatology (Hoboken, N.J.) 2019. PMID: 31637878


  2. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Science translational medicine 2015. PMID: 25995219


  3. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Volume 43 of Issue 8. 2013. PMID: 23630120


  4. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PloS one 2011. PMID: 21886823


  5. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. The Journal of biological chemistry 2010. PMID: 21036901


  6. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. Journal of leukocyte biology 2010. PMID: 20200401


  7. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Volume 107 of Issue 8. Proceedings of the National Academy of Sciences of the United States of America 2010. PMID: 20133674


  8. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Volume 109 of Issue 4. 2009. PMID: 19302484


  9. Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. Journal of Experimental Medicine 2009. PMID:


  10. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. The Journal of cell biology 2009. PMID: 19171755


  11. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. Tim-2 is the receptor for H-ferritin on oligodendrocytes. Journal of neurochemistry 2008. PMID: 19014383


  12. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. The Journal of biological chemistry 2008. PMID: 18411281


  13. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Volume 76 of Issue 6. 2008. PMID: 18391000


  14. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proceedings of the National Academy of Sciences of the United States of America 2006. PMID: 16945906


  15. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. Volume 177 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16887962


  16. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Volume 21 of Issue 2. 2005. PMID: 16418779


  17. Seaman WE. Clinical academic rheumatology: comment on the article by Wickersham et al. Arthritis and rheumatism 2005. PMID: 16208663


  18. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. Volume 202 of Issue 7. 2005. PMID: 16203866


  19. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. Journal of immunology (Baltimore, Md. : 1950) 2004. PMID: 15585835


  20. Chen TT, Brown EJ, Huang EJ, Seaman WE. Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer research 2004. PMID: 14729615


  21. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Volume 171 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 14662855


  22. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 12847223


  23. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature 2002. PMID: 12478301


  25. Nakamura MC, Seaman WE. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunological reviews 2001. PMID: 11513135


  26. Daws MR, Lanier LL, Seaman WE, Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. European journal of immunology 2001. PMID: 11241283


  27. Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE. Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d). The Journal of experimental medicine 2000. PMID: 10934233


  28. Seaman WE. Natural killer cells and natural killer T cells. Arthritis and rheumatism 2000. PMID: 10857779


  29. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. Journal of immunology (Baltimore, Md. : 1950) 1999. PMID: 10528166


  30. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. The Journal of experimental medicine 1999. PMID: 9927511


  31. McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. The Journal of biological chemistry 1998. PMID: 9830044


  32. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9637511


  33. Rolstad B, Seaman WE. Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology. Scandinavian journal of immunology 1998. PMID: 9627124


  34. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. The Journal of experimental medicine 1997. PMID: 9034146


  35. Ryan JC, Seaman WE. Divergent functions of lectin-like receptors on NK cells. Immunological reviews 1997. PMID: 9059884


  36. William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eréne Niemi. Recognition and Signaling by Mouse Ly-49 Receptors. Molecular Basis of NK Cell Recognition and Function 1996. PMID:


  37. William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eré;ne Niemi. Recognition and Signaling by Mouse Ly-49 Receptors. A pilot telephone-based intervention for patients with poorly-controlled diabetes mellitus. 1996. PMID:


  39. Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E. Recognition and signaling by mouse Ly-49 receptors. Chemical immunology 1996. PMID: 8942069


  40. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. The Journal of experimental medicine 1995. PMID: 7722466


  41. Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. A family of murine NK cell receptors specific for target cell MHC class I molecules. Seminars in immunology 1995. PMID: 7579199


  42. Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity 1994. PMID: 7895167


  43. Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. The Journal of experimental medicine 1994. PMID: 8046342


  44. Yokoyama WM, Seaman WE. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annual review of immunology 1993. PMID: 8476574


  45. Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. Journal of immunology (Baltimore, Md. : 1950) 1992. PMID: 1506685


  46. Bell GM, Seaman WE, Niemi EC, Imboden JB. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. The Journal of experimental medicine 1992. PMID: 1346273


  47. Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE. NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 1919012


  48. Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 1680927


  49. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 2033247


  50. Imboden JB, Bell G, Seaman WE. Characterization of signal-transducing molecules on natural killer cells. Biochemical Society transactions 1991. PMID: 1679728


  52. Imboden JB, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE. Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. Journal of immunology (Baltimore, Md. : 1950) 1989. PMID: 2809220


  53. Carteron NL, Wofsy D, Seaman WE. Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells. Volume 140 of Issue 3. Journal of immunology (Baltimore, Md. : 1950) 1988. PMID: 2448372


  54. Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH. Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes. Annals of the New York Academy of Sciences 1988. PMID: 2837968


  55. Seaman WE, Wofsy D. Selective manipulation of the immune response in vivo by monoclonal antibodies. Annual review of medicine 1988. PMID: 3285774


  56. Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE. Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. Arthritis and rheumatism 1987. PMID: 3311051


  57. Harper SE, Roubinian JR, Seaman WE. Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction. The Journal of experimental medicine 1987. PMID: 2957456


  58. Seaman WE, Sleisenger M, Eriksson E, Koo GC. Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3584981


  60. Wofsy D, Seaman WE. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3106478


  61. William E. Seaman, Nancy Gutstein, David Wofsy. In vivo effects of antilymphocyte antibodies on immunity and autoimmunity. Memórias do Instituto Oswaldo Cruz 1987. PMID:


  62. Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman WE. Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells. Transplantation 1986. PMID: 2947360


  63. Gutstein NL, Seaman WE, Scott JH, Wofsy D. Induction of immune tolerance by administration of monoclonal antibody to L3T4. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 3090139


  64. Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W. Cocaine increases natural killer cell activity. The Journal of clinical investigation 1986. PMID: 2937807


  66. Wofsy D, Mayes DC, Woodcock J, Seaman WE. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3160776


  67. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE. Human synovial dendritic cells. Direct observation of transition to fibroblasts. The Journal of rheumatology 1985. PMID: 3863955


  68. Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL. Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells. Digestive diseases and sciences 1985. PMID: 3881233


  69. Wofsy D, Seaman WE. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. The Journal of experimental medicine 1985. PMID: 3919141


  70. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE. Treatment of murine lupus with monoclonal anti-T cell antibody. Volume 134 of Issue 2. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3871218


  72. Seaman WE, Woodcock J. Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid. The Journal of allergy and clinical immunology 1984. PMID: 6432881


  74. Wofsy D, Kerger CE, Seaman WE. Monocytosis in the BXSB model for systemic lupus erythematosus. The Journal of experimental medicine 1984. PMID: 6363600


  75. Seaman WE. Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation. Journal of immunology (Baltimore, Md. : 1950) 1983. PMID: 6417236


  76. Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N. Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. Arthritis and rheumatism 1983. PMID: 6882489


  77. Seaman WE, Wofsy D, Greenspan JS, Ledbetter JA. Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. Journal of immunology (Baltimore, Md. : 1950) 1983. PMID: 6187819


  78. Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N. Thymic influences on autoimmunity in MRL-lpr mice. Scandinavian journal of immunology 1982. PMID: 6981841


  79. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. The Journal of clinical investigation 1982. PMID: 7076851


  80. Ledbetter JA, Seaman WE. The Lyt-2, Lyt-3 macromolecules: structural and functional studies. Immunological reviews 1982. PMID: 6757107


  81. Loeb JM, Talal N, Abensohn-Lee M, Seaman WE. Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin. Journal of clinical & laboratory immunology 1981. PMID: 6175754


  82. Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA. Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity. Journal of immunology (Baltimore, Md. : 1950) 1981. PMID: 6790624


  83. Seaman WE, Talal N. Natural killing by spleen cells from W/Wv and Sl/Sld anemic mice. Experimental hematology 1981. PMID: 7318972


  84. Ledbetter JA, Seaman WE, Tsu TT, Herzenberg LA. Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity. The Journal of experimental medicine 1981. PMID: 6166718


  85. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters. The Journal of clinical investigation 1981. PMID: 6939690


  86. Seaman WE, Blackman MA, Greenspan JS, Talal N. Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice. Journal of immunology (Baltimore, Md. : 1950) 1980. PMID: 6985937


  87. William E. Seaman, Norman Talal. THE EFFECT OF 17ß-ESTRADIOL ON NATURAL KILLING IN THE MOUSE. Natural Cell-mediated Immunity Against Tumors 1980. PMID:


  88. Seaman WE, Merigan TC, Talal N. Natural killing in estrogen-treated mice responds poorly to poly I.C despite normal stimulation of circulating interferon. Journal of immunology (Baltimore, Md. : 1950) 1979. PMID: 227961


  89. Seaman WE, Gindhart TD. Effect of estrogen on natural killer cells. Arthritis and rheumatism 1979. PMID: 389248


  90. Seaman WE, Gindhart TD, Greenspan JS, Blackman MA, Talal N. Natural killer cells, bone, and the bone marrow: studies in estrogen-treated mice and in congenitally osteopetrotic (mi/mi) mice. Journal of immunology (Baltimore, Md. : 1950) 1979. PMID: 376736


  91. Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N. beta-Estradiol reduces natural killer cells in mice. Journal of immunology (Baltimore, Md. : 1950) 1978. PMID: 722074


  92. Seaman WE. Hepatic injury due to acetaminophen or salicylates. The Western journal of medicine 1978. PMID: 18748273


  93. Plotz P, Kimberly R, Gill JR, Seaman W. Letter: Effect of salicylates on creatinine clearance. British medical journal 1976. PMID: 947455


  94. Seaman WE, Plotz PH. Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers. Arthritis and rheumatism 1976. PMID: 1259798


  95. Decker JL, Steinberg AD, Gershwin ME, Seaman WE, Klippel JH, Plotz PH, Paget SA. Systemic lupus erythematosus. Contrasts and comparisons. Annals of internal medicine 1975. PMID: 1115477


  96. Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. Clinical orthopaedics and related research 1974. PMID: 4837924


  97. Seaman WE, Plotz PH, Ishak KG. Proceedings: Aspirin-induced hepatotoxicity in patients with RA or systemic lupus erythematosus (SLE). Arthritis and rheumatism 1974. PMID: 4825655


  98. Seaman WE, Ishak KG, Plotz PH. Letter: Aspirin and hepatotoxicity: addendum. Annals of internal medicine 1974. PMID: 4811807


  99. Seaman WE, Ishak KG, Plotz PH. Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. Annals of internal medicine 1974. PMID: 4810348