William Seaman, MD


2018 - Diversity, Equity, and Inclusion Champion Training, University of California
MD, 1969 - Medicine, Harvard Medical School
  1. Craft JE, Crow MK, Diamond B, Elkon KB, Flood J, Fox DA, Gabriel SE, Gilkeson GS, Hahn BH, Hardin JA, Koopman WJ, Lockshin MD, Salmon JE, Seaman WE, Sergent JS, Uknis AB, Weinblatt ME, Wofsy D. Georgia Abortion Law and our Commitment to Patients. 2019. PMID: 31637878

  2. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. 2015. PMID: 25995219

  3. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Volume 43 of Issue 8. 2013. PMID: 23630120

  4. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. 2011. PMID: 21886823

  5. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. 2010. PMID: 21036901

  6. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. 2010. PMID: 20200401

  7. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Volume 107 of Issue 8. 2010. PMID: 20133674

  8. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Volume 109 of Issue 4. 2009. PMID: 19302484

  9. Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. 2009. PMID:

  10. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. 2009. PMID: 19171755

  11. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. Tim-2 is the receptor for H-ferritin on oligodendrocytes. 2008. PMID: 19014383

  12. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. 2008. PMID: 18411281

  13. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Volume 76 of Issue 6. 2008. PMID: 18391000

  14. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. 2006. PMID: 16945906

  15. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. Volume 177 of Issue 4. 2006. PMID: 16887962

  16. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Volume 21 of Issue 2. 2005. PMID: 16418779

  17. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. Volume 202 of Issue 7. 2005. PMID: 16203866

  18. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. 2004. PMID: 15585835

  19. Chen TT, Brown EJ, Huang EJ, Seaman WE. Expression and activation of signal regulatory protein alpha on astrocytomas. 2004. PMID: 14729615

  20. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Volume 171 of Issue 12. 2003. PMID: 14662855

  21. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. 2003. PMID: 12847223

  22. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. 2002. PMID: 12478301

  23. Nakamura MC, Seaman WE. Ligand interactions by activating and inhibitory Ly-49 receptors. 2001. PMID: 11513135

  24. Daws MR, Lanier LL, Seaman WE, Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. 2001. PMID: 11241283

  25. Seaman WE. Natural killer cells and natural killer T cells. 2000. PMID: 10857779

  26. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. 1999. PMID: 10528166

  27. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. 1999. PMID: 9927511

  28. McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. 1998. PMID: 9830044

  29. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. 1998. PMID: 9637511

  30. Ryan JC, Seaman WE. Divergent functions of lectin-like receptors on NK cells. 1997. PMID: 9059884

  31. William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eréne Niemi. Recognition and Signaling by Mouse Ly-49 Receptors. 1996. PMID:

  32. William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eré;ne Niemi. Recognition and Signaling by Mouse Ly-49 Receptors. 1996. PMID:

  33. Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E. Recognition and signaling by mouse Ly-49 receptors. 1996. PMID: 8942069

  34. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. 1995. PMID: 7722466

  35. Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. A family of murine NK cell receptors specific for target cell MHC class I molecules. 1995. PMID: 7579199

  36. Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. 1994. PMID: 7895167

  37. Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. 1994. PMID: 8046342

  38. Imboden JB, Bell G, Seaman WE. Characterization of signal-transducing molecules on natural killer cells. 1991. PMID: 1679728

  39. Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH. Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes. 1988. PMID: 2837968

  40. Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE. Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. 1987. PMID: 3311051

  41. William E. Seaman, Nancy Gutstein, David Wofsy. In vivo effects of antilymphocyte antibodies on immunity and autoimmunity. 1987. PMID:

  42. Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman WE. Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells. 1986. PMID: 2947360

  43. Gutstein NL, Seaman WE, Scott JH, Wofsy D. Induction of immune tolerance by administration of monoclonal antibody to L3T4. 1986. PMID: 3090139

  44. Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W. Cocaine increases natural killer cell activity. 1986. PMID: 2937807

  45. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE. Human synovial dendritic cells. Direct observation of transition to fibroblasts. 1985. PMID: 3863955

  46. Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL. Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells. 1985. PMID: 3881233

  47. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE. Treatment of murine lupus with monoclonal anti-T cell antibody. Volume 134 of Issue 2. 1985. PMID: 3871218

  48. Wofsy D, Kerger CE, Seaman WE. Monocytosis in the BXSB model for systemic lupus erythematosus. 1984. PMID: 6363600

  49. Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N. Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. 1983. PMID: 6882489

  50. Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N. Thymic influences on autoimmunity in MRL-lpr mice. 1982. PMID: 6981841

  51. Ledbetter JA, Seaman WE. The Lyt-2, Lyt-3 macromolecules: structural and functional studies. 1982. PMID: 6757107

  52. Loeb JM, Talal N, Abensohn-Lee M, Seaman WE. Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin. 1981. PMID: 6175754

  53. Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA. Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity. 1981. PMID: 6790624

  54. Seaman WE, Blackman MA, Greenspan JS, Talal N. Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice. 1980. PMID: 6985937

  55. William E. Seaman, Norman Talal. THE EFFECT OF 17ß-ESTRADIOL ON NATURAL KILLING IN THE MOUSE. 1980. PMID:

  56. Seaman WE, Gindhart TD. Effect of estrogen on natural killer cells. 1979. PMID: 389248

  57. Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N. beta-Estradiol reduces natural killer cells in mice. 1978. PMID: 722074

  58. Seaman WE. Hepatic injury due to acetaminophen or salicylates. 1978. PMID: 18748273

  59. Plotz P, Kimberly R, Gill JR, Seaman W. Letter: Effect of salicylates on creatinine clearance. 1976. PMID: 947455

  60. Decker JL, Steinberg AD, Gershwin ME, Seaman WE, Klippel JH, Plotz PH, Paget SA. Systemic lupus erythematosus. Contrasts and comparisons. 1975. PMID: 1115477

  61. Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. 1974. PMID: 4837924

  62. Seaman WE, Ishak KG, Plotz PH. Letter: Aspirin and hepatotoxicity: addendum. 1974. PMID: 4811807

  63. Seaman WE, Ishak KG, Plotz PH. Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. 1974. PMID: 4810348