William Seaman, MD

Professor

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
MD, 1969 - Medicine, Harvard Medical School
Websites
Publications
  1. Craft JE, Crow MK, Diamond B, Elkon KB, Flood J, Fox DA, Gabriel SE, Gilkeson GS, Hahn BH, Hardin JA, Koopman WJ, Lockshin MD, Salmon JE, Seaman WE, Sergent JS, Uknis AB, Weinblatt ME, Wofsy D. Georgia Abortion Law and our Commitment to Patients. 2019. PMID: 31637878


  2. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. 2015. PMID: 25995219


  3. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Volume 43 of Issue 8. 2013. PMID: 23630120


  4. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. 2011. PMID: 21886823


  5. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. 2010. PMID: 21036901


  6. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. 2010. PMID: 20200401


  7. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Volume 107 of Issue 8. 2010. PMID: 20133674


  8. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Volume 109 of Issue 4. 2009. PMID: 19302484


  9. Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. 2009. PMID:


  10. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. 2009. PMID: 19171755


  11. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. Tim-2 is the receptor for H-ferritin on oligodendrocytes. 2008. PMID: 19014383


  12. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. 2008. PMID: 18411281


  13. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Volume 76 of Issue 6. 2008. PMID: 18391000


  14. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. 2006. PMID: 16945906


  15. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. Volume 177 of Issue 4. 2006. PMID: 16887962


  16. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. Volume 21 of Issue 2. 2005. PMID: 16418779


  17. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. Volume 202 of Issue 7. 2005. PMID: 16203866


  18. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. 2004. PMID: 15585835


  19. Chen TT, Brown EJ, Huang EJ, Seaman WE. Expression and activation of signal regulatory protein alpha on astrocytomas. 2004. PMID: 14729615


  20. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Volume 171 of Issue 12. 2003. PMID: 14662855


  21. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. 2003. PMID: 12847223


  22. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. 2002. PMID: 12478301


  23. Nakamura MC, Seaman WE. Ligand interactions by activating and inhibitory Ly-49 receptors. 2001. PMID: 11513135


  24. Daws MR, Lanier LL, Seaman WE, Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. 2001. PMID: 11241283


  25. Seaman WE. Natural killer cells and natural killer T cells. 2000. PMID: 10857779


  26. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. 1999. PMID: 10528166


  27. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. 1999. PMID: 9927511


  28. McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. 1998. PMID: 9830044


  29. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. 1998. PMID: 9637511


  30. Ryan JC, Seaman WE. Divergent functions of lectin-like receptors on NK cells. 1997. PMID: 9059884


  31. William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eréne Niemi. Recognition and Signaling by Mouse Ly-49 Receptors. 1996. PMID:


  32. Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E. Recognition and signaling by mouse Ly-49 receptors. 1996. PMID: 8942069


  33. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. 1995. PMID: 7722466


  34. Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. A family of murine NK cell receptors specific for target cell MHC class I molecules. 1995. PMID: 7579199


  35. Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. 1994. PMID: 7895167


  36. Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. 1994. PMID: 8046342


  37. Imboden JB, Bell G, Seaman WE. Characterization of signal-transducing molecules on natural killer cells. 1991. PMID: 1679728


  38. Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH. Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes. 1988. PMID: 2837968


  39. Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE. Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. 1987. PMID: 3311051


  40. William E. Seaman, Nancy Gutstein, David Wofsy. In vivo effects of antilymphocyte antibodies on immunity and autoimmunity. 1987. PMID:


  41. Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman WE. Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells. 1986. PMID: 2947360


  42. Gutstein NL, Seaman WE, Scott JH, Wofsy D. Induction of immune tolerance by administration of monoclonal antibody to L3T4. 1986. PMID: 3090139


  43. Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W. Cocaine increases natural killer cell activity. 1986. PMID: 2937807


  44. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE. Human synovial dendritic cells. Direct observation of transition to fibroblasts. 1985. PMID: 3863955


  45. Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL. Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells. 1985. PMID: 3881233


  46. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE. Treatment of murine lupus with monoclonal anti-T cell antibody. Volume 134 of Issue 2. 1985. PMID: 3871218


  47. Wofsy D, Kerger CE, Seaman WE. Monocytosis in the BXSB model for systemic lupus erythematosus. 1984. PMID: 6363600


  48. Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N. Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. 1983. PMID: 6882489


  49. Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N. Thymic influences on autoimmunity in MRL-lpr mice. 1982. PMID: 6981841


  50. Ledbetter JA, Seaman WE. The Lyt-2, Lyt-3 macromolecules: structural and functional studies. 1982. PMID: 6757107


  51. Loeb JM, Talal N, Abensohn-Lee M, Seaman WE. Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin. 1981. PMID: 6175754


  52. Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA. Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity. 1981. PMID: 6790624


  53. Seaman WE, Blackman MA, Greenspan JS, Talal N. Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice. 1980. PMID: 6985937


  54. William E. Seaman, Norman Talal. THE EFFECT OF 17ß-ESTRADIOL ON NATURAL KILLING IN THE MOUSE. 1980. PMID:


  55. Seaman WE, Gindhart TD. Effect of estrogen on natural killer cells. 1979. PMID: 389248


  56. Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N. beta-Estradiol reduces natural killer cells in mice. 1978. PMID: 722074


  57. Seaman WE. Hepatic injury due to acetaminophen or salicylates. 1978. PMID: 18748273


  58. Plotz P, Kimberly R, Gill JR, Seaman W. Letter: Effect of salicylates on creatinine clearance. 1976. PMID: 947455


  59. Decker JL, Steinberg AD, Gershwin ME, Seaman WE, Klippel JH, Plotz PH, Paget SA. Systemic lupus erythematosus. Contrasts and comparisons. 1975. PMID: 1115477


  60. Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. 1974. PMID: 4837924


  61. Seaman WE, Ishak KG, Plotz PH. Letter: Aspirin and hepatotoxicity: addendum. 1974. PMID: 4811807


  62. Seaman WE, Ishak KG, Plotz PH. Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. 1974. PMID: 4810348